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Optical imaging of neuronal connections and understanding the mechanisms of signal transformation between areas TEO and TE

Research Project

Project/Area Number 26750383
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Nakamichi Yu  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (70586164)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsオプトジェネティクス / 光内因性信号イメージング / 視覚
Outline of Final Research Achievements

Visual information is hierarchically processed in multiple cortical areas along ventral stream. In this study, to explore how the visual information is transformed between final stages of visual processing, areas TEO and TE, a technique to identify cortico-cortical projection patterns was developed using optogenetics and optical intrinsic signal imaging. For validation, the technique was applied to well-known callosal connections in V1/V2 border. The results showed reproducible projection patterns and those were confirmed with electrophysiological recordings. The technique was applied to unknown connections between TEO and TE, and reproducible projection patterns were also obtained. Therefore, mechanisms of visual information transformation between areas TEO and TE can be revealed by combination of the cortico-cortical projection mapping and electrophysiological recording.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2014

All Presentation (4 results)

  • [Presentation] Combination of optogenetics and optical imaging to identify unknown cortico-cortical projection patterns in macaque2014

    • Author(s)
      Yu Nakamichi, Mitsuhiro Hashimoto, Naohito Kitamura, Kei Hagiya, Takayuki Sato, Manabu Tanifuji
    • Organizer
      東京大学医学部統合生理学教室シンポジウム
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report
  • [Presentation] The singularity string: a revised structure of pinwheel in cat orientation columns revealed by functional optical coherence tomography2014

    • Author(s)
      Manabu Tanifuji, Yu Nakamichi, Valery A. Kalatsky, Hideyuki Watanabe, Takayuki Sato, Uma Maheswari Rajagopalan
    • Organizer
      東京大学医学部統合生理学教室シンポジウム
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report
  • [Presentation] A combination study of optogenetics and optical imaging to identify unknown cortico-cortical projection patterns in macaque2014

    • Author(s)
      Yu Nakamichi, Mitsuhiro Hashimoto, Naohito Kitamura, Kei Hagiya, Takayuki Sato, Manabu Tanifuji
    • Organizer
      Neuroscience 2014 (Society for Neuroscience)
    • Place of Presentation
      Walter E. Washington Convention Center (Washington, DC, USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Identifying unknown cortico-cortical projection patterns in macaque using optogenetics and optical imaging2014

    • Author(s)
      Yu Nakamichi, Mitsuhiro Hashimoto, Naohito Kitamura, Kei Hagiya, Takayuki Sato, Manabu Tanifuji
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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