Dynamic change of hippocampal theta activity and synaptic plasticity with the memory encoding for negative episode
| Project/Area Number |
26780419
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SAKIMOTO Yuya 山口大学, 医学(系)研究科(研究院), 助教 (40634390)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 海馬CA1 / エピソード記憶 / patch clamp / ニューロン / シナプス可塑性 / 回避学習 |
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| Outline of Final Research Achievements |
This project examined the synaptic plasticity after presentation negative episode (foot shock) by using Inhibitory avoidance task. We recorded mEPSCs (excitatory postsynaptic currents) and mIPSCs (miniature inhibitory postsynaptic currents) at the 0, 5, 10, 20, 30 min after presentation of episode. The results showed the increase of mEPSCs and mIPSCs from 5 min after presentation of episode. These increase of mEPSCs and mIPSCs showed an increasing numbers of AMPA and GABAA receptors on hippocampal CA1 spine. Thus, we propose that the encoding of negative episode memory induced the synaptic plasticity in hippocampal CA1 neuron within 5 min.
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Report
(3 results)
Research Products
(3 results)
