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Neural circuit of the serotonin for promoting reward waiting behavior: Examination by optical stimulation

Research Project

Project/Area Number 26780423
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

Miyazaki Kayoko  沖縄科学技術大学院大学, 神経計算ユニット, 研究員 (80426577)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsセロトニン / 光操作 / 報酬待機行動 / 光刺激 / 遅延報酬 / 辛抱強さ
Outline of Final Research Achievements

Based on the results from our studies, we proposed a new concept about serotonin: the forebrain serotonergic system is involved in reducing behavioral activity not only to avoid aversive events with a prediction of punishment, but also to obtain a reward with a prediction of reward.
To test them, we used transgenic mice that express the channelrhodopsin-2 (ChR2) variant C128S, a step-function opsin, in serotonin neurons and showed that the selective activation of serotonin neurons in some projection site of DRN serotonin neuron enhances the patience of mice in waiting for both the conditioned reinforcer tone and food reward. We are continuing experiments to investigate it further.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] 背側縫線核と辛抱強さ2016

    • Author(s)
      宮崎勝彦, 宮崎佳代子, 銅谷賢治
    • Journal Title

      分子精神医学

      Volume: 16 Pages: 2-10

    • Related Report
      2015 Research-status Report
  • [Journal Article] 報酬待機行動とセロトニン:神経活動の光活性化による検証2015

    • Author(s)
      宮崎佳代子, 宮崎勝彦, 銅谷賢治
    • Journal Title

      光学

      Volume: 44 Pages: 422-426

    • Related Report
      2015 Research-status Report
  • [Journal Article] Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards.2014

    • Author(s)
      Miyazaki KW, Miyazaki K, Tanaka KF, Yamanaka A, Takahashi A, Tabuchi S, Doya K
    • Journal Title

      Curr Biol

      Volume: 24 Issue: 17 Pages: 2033-2040

    • DOI

      10.1016/j.cub.2014.07.041

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Serotonin and Patience2015

    • Author(s)
      Miyazaki K, Miyazaki KW, Doya K
    • Organizer
      92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Promotion of patience by dorsal raphe serotonin neuron activation depends on the certainty of future rewards.2014

    • Author(s)
      Miyazaki K, Miyazaki KW, Tanaka KF, Yamanaka A, Takahashi A, Doya, K.
    • Organizer
      44th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards.2014

    • Author(s)
      Miyazaki K, Miyazaki KW, Tanaka KF, Yamanaka A, Takahashi A, Doya K
    • Organizer
      29th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Book] 報酬のための辛抱強さを調節するセロトニンの役割2015

    • Author(s)
      宮崎佳代子、宮崎勝彦、銅谷賢治
    • Total Pages
      6
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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