In vivo imaging of transplanted stem cells by OTN-NIR fluorescence quantum dots
| Project/Area Number |
26790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanostructural physics
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| Research Institution | Nagoya University |
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Principal Investigator |
Yukawa Hiroshi 名古屋大学, 工学研究科, 特任講師 (30634646)
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| Co-Investigator(Renkei-kenkyūsha) |
Baba Yoshinobu 名古屋大学, 大学院工学研究科, 教授 (30183916)
Ishikawa Tetsuya 名古屋大学, 大学院医学系研究科, 教授 (10288508)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 量子ドット / 幹細胞 / イメージング / OTN-NIR蛍光 / in vivo / in vivoイメージング / 応用光学 / ナノバイオ / 再生医学 / 細胞・組織 / 応用光学・量子光工学 |
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| Outline of Final Research Achievements |
Nobel Cd free quantum dots (QDs) which emit 1,000 nm wavelength fluorescence at infrared region with high compatibility were synthesized, and optical properties (fluorescence intensity, quantum yield, life time, and stability) of the QDs were checked. In addition, the transduction efficiency and cytotoxicity of the QDs to stem cells were investigated, and the self-proliferation and multipotency of stem cells labeled with QDs were checked. Moreover, in vivo fluorescence imaging of transplanted stem cells labeled with QDs were addressed and was found to be useful for the assessment of acute liver failure mice.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Correlative near-infrared light and cathodoluminescence microscopy using Y2O3:Ln, Yb (Ln = Tm, Er) nanophosphors for multi-scale, multi-colour bioimaging2016
Author(s)
Fukushima, S., Furukawa, T., Niioka, H., Ichimiya, M., Sannomiya, T., Tanaka, N., Onoshima, D., Yukawa, H., Baba, Y., Miyake, J., Ashida, M., Araki, T., and Hashimoto, M.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 25950-25950
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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