| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Microstructures in the liver are primarily composed of hepatocyte, hepatic blood, and biliary vessels. Because each hepatocyte comes in contact with hepatic blood, and biliary vessels, these vessels and the hepatocyte cord form 3D periodic network patterns. We have elucidated the morphogenesis of 3D microstructures in liver using imaging data of diseased rat liver. Based on the confocal image of hepatocyte and blood vessels in diseased liver and the quantitative data of blood flow, we have performed an allometric analysis of 3D morphological changes in liver. We also discuss the physical effect to morphogenesis by using the fractal index of patterns of the blood vessel.
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