| Project/Area Number |
26800276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Geochemistry/Cosmochemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Kitadai Norio 東京工業大学, 地球生命研究所, WPI研究員 (80625723)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 生命の起源 / アストロバイオロジー / 化学進化 / ペプチド / アミノ酸 / 生命の化学進化 |
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| Outline of Final Research Achievements |
In this study, I have examined the synthetic and polymerization behaviors of amino acids under various conditions. I determined a complete set of thermodynamic parameters for the 20 protein amino acids, three short peptides, and four non-protein amino acids. Calculations using the dataset suggested that Hadean alkaline hydrothermal settings, where steep pH and temperature gradients may have existed between cool, slightly acidic Hadean ocean water and hot, alkaline hydrothermal fluids at the vent-ocean interface, is energetically the most suitable environment for the synthesis and polymerization of protein-amino acids. As an experimental approach, I have examined the polymerization of glycine on nine oxide minerals. Polymerization activation was inferred to have arisen from deprotonation of the NH3+ group of adsorbed Gly to the nucleophilic NH2 group, and from withdrawal of electron density from the carboxyl carbon to the surface metal ions.
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