Universal Methodology for Drug Development Based on Stimuli-responsive Molecular Glues
| Project/Area Number |
26810046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional solid state chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Okuro Kou 東京大学, 工学(系)研究科(研究院), 助教 (60614360)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子糊 / 刺激応答性 / 光重合 / siRNA / ATP / 酵素阻害剤 / 酵素 / 鋳型重合 / タンパク質 / 酵素阻害 / 結合力の増強 |
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| Outline of Final Research Achievements |
By conjugation of a molecular glue with an enzyme inhibitor, >30-times binding affinity and >10-times inhibitory effect were achieved. The results support the concept that drug efficacy can be enhanced by simply introducing an “adhesive" moiety. In this research project, we had mainly focused on development of stimuli-responsive molecular glues, though different from the original plan, and succeeded in synthesis of “photo-polymerizable”, “redox-responsive”, and “ATP-binding” molecular glues. Each of the molecular glues demonstrates a remarkable properties to manipulate biological functions. The development of new stimuli-responsive molecular glues will definitely promote the project toward treatment of unmet-needs diseases.
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Report
(3 results)
Research Products
(22 results)
