Development of a Hierarchical Chiral Information Transfer System and Its Application
Project/Area Number |
26810047
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Functional solid state chemistry
|
Research Institution | Nagoya University |
Principal Investigator |
Ousaka Naoki 名古屋大学, 工学(系)研究科(研究院), 講師 (80726331)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | らせん構造 / ペプチド / キラリティ / 超分子化学 |
Outline of Final Research Achievements |
Planar chiral salen-based metallomacrocycles bearing dynamic helical peptide chains were efficiently synthesized through self-assembly of their corresponding ligands, diamines, and metal ions. The planar chirality of the resulting macrocycles can be remotely controlled through an induction of a preferred-handed 310-helical structure in the dynamic oligopeptide chain by a chiral amino acid residue far from the macrocycle framework. The remote-controlled planar chirality was almost completely locked as a result of a solvent-induced 310-to-α-helix transition of the pendant peptide chains. In addition, remote stereocontrol of an axially chiral bipyridine bearing dynamic helical peptide chains was also achieved.
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Report
(3 results)
Research Products
(51 results)