| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
Cross-coupling reaction is a versatile method for carbon-carbon bond constructions. Cross-coupling reactions generally require pre-synthesis and purification of organometallics prior to the desired carbon-carbon bond formation. In contrast to the conventional cross-coupling reactions, cross-coupling reactions based on catalytically generated organometallics are more atom- and step-economical. Here, we have developed alkylation and alkenylation of organic electrophiles based on catalytically generated organocoppers via hydrocupration, borylcupration, and carbocupration of alkenes and alkynes. These reactions can afford highly functionalized alkanes and alkenes from readily available starting materials in highly step- and atom-economical manners.
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