Cross-Coupling Reactions Based on Catalytically Generated Organometallics via Addition of Metal Species
Project/Area Number |
26810058
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Synthetic chemistry
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Keywords | クロスカップリング反応 / 金属協働触媒 / クロスカップリング / パラジウム / 銅 / ヒドロアリール化 / カルボホウ素化 / アリールホウ素化 / アルキン / アルケン / 交差カップリング反応 |
Outline of Final Research Achievements |
Cross-coupling reaction is a versatile method for carbon-carbon bond constructions. Cross-coupling reactions generally require pre-synthesis and purification of organometallics prior to the desired carbon-carbon bond formation. In contrast to the conventional cross-coupling reactions, cross-coupling reactions based on catalytically generated organometallics are more atom- and step-economical. Here, we have developed alkylation and alkenylation of organic electrophiles based on catalytically generated organocoppers via hydrocupration, borylcupration, and carbocupration of alkenes and alkynes. These reactions can afford highly functionalized alkanes and alkenes from readily available starting materials in highly step- and atom-economical manners.
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Report
(5 results)
Research Products
(41 results)