Development Study of New Environmentally Friendly Antifouling Agents by Mimicking Marine Natural Products
| Project/Area Number |
26810061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 天然物合成 / 着性阻害活性 / 不斉合成 / ヨウ化サマリウム / 構造活性相関 |
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| Outline of Final Research Achievements |
Synthetic study toward the total synthesis of dolastane-type diterpene, a marine natural product which exhibit potent antifouling activity against the mussel, was carried out to develop new antifouling agent for ship. Toward the total synthesis of dolastane-type diterpene, the construction of the bicyclo[5. 4. 0]undecane skeleton was achieved by utilizing the reductive Knoevenagel condensation with Hantzsch ester, the Corey-Bakshi-Shibata asymmetric reduction, and the SmI2-initiated radical cyclization as key steps. And synthesis of cis-fused bicyclic skeleton of toxicodenane A, a sesquiterpene derived from the family anacardiaceae, was also accomplished according to the above synthetic method.
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Report
(4 results)
Research Products
(93 results)
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[Presentation] Studies on Total Synthesis of Histrionicotoxins2016
Author(s)
Kunihiro Matsumura, Keisuke Nishikawa, Yoshimitsu Tachi, and Yoshiki Morimoto
Organizer
The 20th Osaka City University International Conference ( 20th OCUIC ) on Molecular Spins and Quantum Technology
Place of Presentation
大阪市立大学 学術情報総合センター ( 大阪府大阪市住吉区 )
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] Synthetic Studies on Tetrodotoxin Model Compound2016
Author(s)
Yusuke Araki, Takahiro Maruyama, Seiho Kikuchi, Keisuke Nishikawa, Yoshimitsu Tachi, and Yoshiki Morimoto
Organizer
The 20th Osaka City University International Conference ( 20th OCUIC ) on Molecular Spins and Quantum Technology
Place of Presentation
大阪市立大学 学術情報総合センター ( 大阪府大阪市住吉区 )
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] 5,6-Dehydrokawain and Synthetic Analogs Stimulate Osteoblastic MC3T3-E1 Cells2015
Author(s)
Momochika Kumagai, Takeshi Mishima, Akio Watanabe, Teppei Harada, Masahiro Ide, Keiko Koizumi, Izumi Yoshida, Kazuhiro Fujita, Masatoshi Watai, Keisuke Nishikawa, and Yoshiki Morimoto
Organizer
The 19th Osaka City University International Workshop on Advanced Molecular Materials Science (19th OCUIC)
Place of Presentation
大阪市立大学(大阪府大阪市)
Year and Date
2015-11-12
Related Report
Int'l Joint Research
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[Presentation] Total Syntheses of Lepadiformines2015
Author(s)
Kengo Yamauchi, Seiho Kikuchi, Shinnosuke Ezaki, Tomoyuki Koyama, Keisuke Nishikawa, Yoshimistu Tachi, and Yoshiki Morimoto
Organizer
The 19th Osaka City University International Workshop on Advanced Molecular Materials Science (19th OCUIC)
Place of Presentation
大阪市立大学(大阪府大阪市)
Year and Date
2015-11-12
Related Report
Int'l Joint Research
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[Presentation] Studies on Total Synthesis of (-)-Histrionicotoxin2015
Author(s)
Kunihiro Matsumura, Keisuke Nishikawa, Yoshimitsu Tachi, and Yoshiki Morimoto
Organizer
The 19th Osaka City University International Workshop on Advanced Molecular Materials Science (19th OCUIC)
Place of Presentation
大阪市立大学(大阪府大阪市)
Year and Date
2015-11-12
Related Report
Int'l Joint Research
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