| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Synthetic study toward the total synthesis of dolastane-type diterpene, a marine natural product which exhibit potent antifouling activity against the mussel, was carried out to develop new antifouling agent for ship. Toward the total synthesis of dolastane-type diterpene, the construction of the bicyclo[5. 4. 0]undecane skeleton was achieved by utilizing the reductive Knoevenagel condensation with Hantzsch ester, the Corey-Bakshi-Shibata asymmetric reduction, and the SmI2-initiated radical cyclization as key steps. And synthesis of cis-fused bicyclic skeleton of toxicodenane A, a sesquiterpene derived from the family anacardiaceae, was also accomplished according to the above synthetic method.
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