Green synthesis of oligopeptides in the inverse direction by a novel, thiol-relay method
| Project/Area Number |
26810062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ペプチド合成 / グリーン合成 / アミド結合形成 / チオカルボン酸 / 環状炭酸無水物 / 高原子効率 / グリーンケミストリー |
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| Outline of Final Research Achievements |
The most reliable and generally used method for preparation of oligopeptides is currently solid-supported synthesis, which requires excess monomers, excess dehydrating agents and protective group manipulations. We consider this classical method to be updated to circumvent its low atom economy, and design a novel method named ‘thiol-relay,’ which discharges only carbon dioxide along with construction of a peptide bond. First, we improved an access to the thiocarboxylic acid, a key function in thiol-relay method, by introducing a novel, easy-to-prepare, and easy-to-handle precursor. The basic concept of thiol-relay peptide synthesis was proven, and we also found some problems toward more practical use of this method.
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Report
(4 results)
Research Products
(2 results)
