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Functional molecular robot using RNA/RNP nanostructures

Research Project

Project/Area Number 26810089
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bio-related chemistry
Research InstitutionOsaka University (2015-2016)
Kyoto University (2014)

Principal Investigator

Shibata Tomonori  大阪大学, 産業科学研究所, 特任助教(常勤) (80711960)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsRNA / タンパク質 / 核酸ナノテクノロジー / RNAナノテクノロジー / RNA-タンパク質複合体 / 核酸ナノ構造 / RNAナノ構造 / 分子ロボット / ナノマシン
Outline of Final Research Achievements

We designed and constructed RNA-protein complex-based functional molecular robots that exert desired funtions in response to proteins. The functional molecular robots consisting of RNA and protein can be constructed within live cells. We demonstrated that mammalian cell fate can be controlled using functional molecular robots. Construction of a molecular robot that functions in a particular cell will be useful for medical applications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2015 2014

All Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Presentation] Synthetic RNA-protein nano machines that function in vitro and in live cell2015

    • Author(s)
      ○Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
    • Organizer
      ISNAC20
    • Place of Presentation
      イーグレ姫路 (兵庫県 姫路市)
    • Year and Date
      2015-09-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] タンパク質応答性RNAナノマシン2015

    • Author(s)
      ○柴田知範、鈴木勇輝、杉山弘、遠藤政幸、齊藤博英
    • Organizer
      日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌 (北海道 札幌市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] A RNA-protein-based nanomachine for controlling functional RNAs2014

    • Author(s)
      Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito
    • Organizer
      The 41st International Symposium on Nucleic Acids Chemistry 2014
    • Place of Presentation
      北九州
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Photo-regulation of RNA-protein-based nanostructures2014

    • Author(s)
      Tomonori Shibata, Kenzo Fujimoto, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Masahiro Takinoue, Hirohide Saito
    • Organizer
      20th International Conference on DNA computing and Molecular Programming
    • Place of Presentation
      京都
    • Year and Date
      2014-09-22 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Book] Methods Mol Biol.2015

    • Author(s)
      Shibata T, Suzuki Y, Sugiyama H, Endo M, Saito H
    • Publisher
      Humana Press
    • Related Report
      2015 Research-status Report
  • [Book] Methods in Molecular Biology 1316 (Chapter 14)2015

    • Author(s)
      Tomonori Shibata, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, and Hirohide Saito
    • Publisher
      Human press
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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