Development of dihydropyrimidine fluorescent probe to detect reactive oxygen species for analysis of in vivo oxidation
| Project/Area Number |
26810095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ジヒドロピリミジン / ピリミジン / 蛍光プローブ / 活性酸素 / 酸化 / ヘテロ環 |
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| Outline of Final Research Achievements |
Development of a new method to detect reactive oxygen species (ROS) in high selectivity and sensitivity for analysis of in vivo oxidation state is a significant research theme. For this purpose, we set up our goal to establish a novel and practical dihydropyrimidine fluorescent probe that is oxidized by ROS to give strongly fluorescent pyrimidine.
In this project, we developed novel methods to synthesize hitherto unavailable 4,6-unsubstituted 2-aminodihydropyrimidines 5-carboxylic acid ethyl esters, 4,6-unsubstituted 5-acyl-2-phenyldihydropyrimidines and 4,6-unsubstituted 5-acyl-2-aminodihydropyrimidines, which expanded dihydropyrimidine-based chemistry.
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Report
(3 results)
Research Products
(8 results)
