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The study of the combination treatment of cryosurgery and hyperthermia treatment and the heat induced disorder for living tissue

Research Project

Project/Area Number 26820065
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thermal engineering
Research InstitutionKitasato University

Principal Investigator

TAKAHASHI Daishi  北里大学, 北里大学保健衛生専門学院, 講師 (20549943)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords凍結手術 / 温熱療法 / 凍結加温手術 / 手術装置 / ペルチェ素子 / 併用療法 / 治療器 / スターリングクーラ
Outline of Final Research Achievements

In this study, the combination treatment system of cryosurgery and hyperthermia treatment was fabricated and evaluated. The therapeutic apparatus consists of the surgical probe using Peltier device, the coolant circulation system and the power with the temperature control function for Peltier device. In the evaluation of the system performances, the temperature cycles that cryosurgery and hyperthermia treatment were alternately repeated three times could be achieved. The combination treatment was operated on the living liver tissue of mouse for confirming the tissue destruction effect. The injuries such as the disappearances of the cell nuclei, the cell dropout and the decrease of the stainability were observed in the HE stained tissue sections under the optical microscope. The results suggest the feasibility of the combination treatment of cryosurgery and hyperthermia treatment and the application potentiality to the endoscope by the downsizing of the system.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 冷媒冷却の性能向上を目的とした凍結加温手術装置の改良2016

    • Author(s)
      髙橋 大志、田口 洋介、相田 武則
    • Journal Title

      北里大学保健衛生専門学院紀要

      Volume: 21 Pages: 27-35

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] エタノール冷媒を用いた凍結加温手術装置の基礎的検討2015

    • Author(s)
      髙橋大志、田口洋介、相田武則
    • Journal Title

      北里大学保健衛生専門学院紀要

      Volume: 20 Pages: 19-25

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ハンドピース型の冷温手術装置の基礎検討 ~冷媒の検討~2015

    • Author(s)
      相田武則、田口洋介、髙橋大志
    • Journal Title

      北里大学保健衛生専門学院紀要

      Volume: 20 Pages: 45-52

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 凍結加温手術装置における温度サイクル性能の評価2016

    • Author(s)
      髙橋大志、田口洋介、相田武則
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 凍結加温手術装置の改良による冷媒への温度影響2015

    • Author(s)
      髙橋大志、田口洋介、相田武則
    • Organizer
      第24回魚沼シンポジア
    • Place of Presentation
      北里大学保健衛生専門学院(新潟県南魚沼市)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fabrication of the combination treatment system of cryosurgery and hyperthermia treatment using Peltier device with ethanol circulation as a coolant2015

    • Author(s)
      Daishi TAKAHASHI, Yousuke TAGUCHI, Takenori AIDA
    • Organizer
      The 8th Asian-Pacific Conference on Biomechanics (AP Biomech 2015)
    • Place of Presentation
      Sapporo Campus of Hokkaido University (Sapporo, Hokkaido)
    • Year and Date
      2015-09-16 – 2015-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Fabrication of the combination treatment system of cryosurgery and hyperthermia treatment using Peltier device with ethanol circulation as a coolant2015

    • Author(s)
      Daishi TAKAHASHI, Yousuke TAGUCHI and Takenori AIDA
    • Organizer
      the 8th Asian-Pacific Conference on Biomechanics
    • Place of Presentation
      Hokkaido University (Sapporo, Japan)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 冷媒循環型の凍結加温手術装置の作製2015

    • Author(s)
      高橋大志、田口洋介、相田武則
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋市・愛知県)
    • Year and Date
      2015-05-07 – 2015-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 冷媒循環型の凍結加温手術装置の作製2015

    • Author(s)
      高橋大志,田口洋介,相田武則
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 冷媒循環型の凍結加温手術装置の試作2014

    • Author(s)
      髙橋大志,田口洋介、相田武則
    • Organizer
      第23回魚沼シンポジア
    • Place of Presentation
      北里大学保健衛生専門学院(南魚沼市・新潟県)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] ハンドピース型の冷温手術装置の基礎検討2014

    • Author(s)
      相田武則、髙橋大志、田口洋介
    • Organizer
      第23回魚沼シンポジア
    • Place of Presentation
      北里大学保健衛生専門学院(南魚沼市・新潟県)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] A Fabrication and an Evaluation of a Handheld Treatment System Combining Cryosurgery with Hyperthermia Treatment2014

    • Author(s)
      Daishi Takahashi, Yousuke Taguchi and Takenori Aida
    • Organizer
      The 53rd Annual Conference of Japanese Society for Medical and Biological Engineering (JSMBE53)
    • Place of Presentation
      仙台国際センター(仙台市・宮城県)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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