| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In the current medical arena, there is a major problem of noncompliance of patients who are reluctant to take bitter medications. The purpose of this study is to develop a taste sensor for detecting bitterness of medicines to improve the problem. I researched a composition distribution of membrane surface and membrane inside of the lipid polymer membrane which is the receiving part of the taste sensor. It was revealed that the sensitivity of the sensor depends not only on the adsorption amount of the bitter substance but also on the membrane surface charge density by the lipid and the plasticizer, and the balance between them is important. I could create statistical model expressions highly correlated with sensory values using sensor response and sensory test data using the fabricated taste sensors for bitterness of medicine and sensor for artificial sweeteners. Therefore, it is considered to be useful as a new method effective in designing bitterness of pharmaceutical products.
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