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Development of high definition multi-wavelength holographic tomography for biological measurement

Research Project

Project/Area Number 26820155
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Measurement engineering
Research InstitutionNiigata University

Principal Investigator

Samuel Choi  新潟大学, 自然科学系, 助教 (60568418)

Co-Investigator(Renkei-kenkyūsha) HIBINO Hiroshi  新潟大学, 医歯学系, 教授 (70314317)
NIN Fumiaki  新潟大学, 医歯学系, 准教授 (80644905)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords光コヒーレンストモグラフィ / 光生体計測 / 光エレクトロニクス / 生体計測 / 生体振動計測 / 光計測 / 計測工学 / 干渉計測 / 内耳 / 蝸牛基底板振動 / 聴覚研究
Outline of Final Research Achievements

In this study, aiming for a high-precision tomographic imaging with nm precision in biological tissues, multi-wavelength holographic high-definition optical coherence tomography technique was developed through medical-engineering cooperation. The "en-face multi-frequency swept OCT" was produced as a practical method of evolutionary principle of multi-wavelength holographic interferometry, which allowed three-dimensional tomographic measurement of biological samples with a resolution of 2.5 micrometer. In addition, we have developed the "wide-field heterodyne interference vibrometry" as a technology that can obtain spatial vibrational distributions within the field of view of the microscope image. The combination of these two basic technologies were able to measure tomographic images and minute vibrations of interior surfaces in a thick bio-tissue at 10 kHz with nm accuracy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Multifrequency swept common-path en-face OCT for wide-field measurement of interior surface vibrations in thick biological tissues2015

    • Author(s)
      S Choi, T Watanabe, T Suzuki, F Nin, H Hibino, O Sasaki
    • Journal Title

      Optics Express

      Volume: 23 Issue: 16 Pages: 21078-21089

    • DOI

      10.1364/oe.23.021078

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Wide-field heterodyneinterferometricvibrometryfor two-dimensionalsurfacevibrationmeasurement2015

    • Author(s)
      S Choi, , Y Maruyama, T Suzuki, F Nin, H Hibino, O Sasaki
    • Journal Title

      Optics Communications

      Volume: 356 Pages: 343-349

    • DOI

      10.1016/j.optcom.2015.08.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Profile Measurement of Thin Films by Backpropagation of Multiple-Wavelength Optical Fields with Two Sinusoidal Phase-Modulating Interferometers2015

    • Author(s)
      O. Sasaki, J. Xin, S. Choi, T. Suzuki
    • Journal Title

      Optics Communications

      Volume: 356 Pages: 578-581

    • DOI

      10.1016/j.optcom.2015.08.066

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phase-shifting interferometer with pulse modulation based on a down sampling technique2015

    • Author(s)
      T. Serizawa, T. Suzuki, and S. Choi
    • Journal Title

      Optical Engineering

      Volume: 54 Issue: 8 Pages: 085107-085107

    • DOI

      10.1117/1.oe.54.8.085107

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional step height measurement using sinusoidal wavelength scanning interferometer with four-step phase-shift method2014

    • Author(s)
      Samuel Choi, Shouhei Takahashi, Osami Sasaki, Takamasa Suzuki
    • Journal Title

      Optical Engineering

      Volume: 53 Issue: 8 Pages: 084110-084115

    • DOI

      10.1117/1.oe.53.8.084110

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-frequency scanning interferometry using variable spatial spectral filter2014

    • Author(s)
      S. Choi, R. Sato, H. Kato, O. Sasaki, and T. Suzuki
    • Journal Title

      Opt. Commun

      Volume: vol. 316 Pages: 168-173

    • DOI

      10.1016/j.optcom.2013.12.015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 3D Tomographic Measurement of Interior Surface Vibrations in Thick Biological Tissuese Using Multifrequency Sweepable Optical Comb2016

    • Author(s)
      S. Choi, K. Sato, F. Nin, and H. Hibino
    • Organizer
      2016 Collaborative Conference on 3D and Materials Research (CC3DMR)
    • Place of Presentation
      韓国仁川International convention center
    • Year and Date
      2016-06-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多波長走査型干渉顕微鏡による生体内部の en-face 断層振動計測【注目講演】2016

    • Author(s)
      崔 森悦、佐藤 敬太、任 書晃、日比野 浩
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都目黒区東京工業大学大岡山キャンパス
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体断層計測用GHz 帯Er 添加高調波能動モード同期 ファイバレーザの製作2016

    • Author(s)
      羽田 圭志、崔 森悦、任 書晃、日比野 浩、 黒川 隆志
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都目黒区東京工業大学大岡山キャンパス
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 広視野ヘテロダイン干渉振動計測法による一括平面振動 計測2016

    • Author(s)
      崔 森悦、丸山 悠太、鈴木 孝昌、小浦方 格
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都目黒区東京工業大学大岡山キャンパス
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] SC 光源と多波長逆伝搬法を用いた高分解能断層形状計測2016

    • Author(s)
      安部 和樹、武隈 雄也、崔 森悦、佐々木 修己、新田 勇、小浦方 格
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都目黒区東京工業大学大岡山キャンパス
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 空間光位相変調器による光渦の生成と位相計測2015

    • Author(s)
      出塚 和紀,崔 森悦, 鈴木孝昌, 佐々木修己
    • Organizer
      平成27年度(第25回)電気学会東京支部新潟支所研究発表会
    • Place of Presentation
      新潟県長岡市 長岡技術科学大学
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Optical multi-frequency swept sensing for wide-field vibration measurement of interior surfaces in biological tissue2015

    • Author(s)
      S. Choi, F. Nin, H. Hibino, and T. Suzuki
    • Organizer
      SPIE/OSJ Biophotonics Japan 2015
    • Place of Presentation
      東京都文京区筑波大学東京キャンパス
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wide-field heterodyne en-face OCT system for vibration measurement of internal surfaces2015

    • Author(s)
      Samuel Choi, Fumiaki Nin, Takamasa Suzuki, and Hiroshi Hibino
    • Organizer
      CLEO-PR2015
    • Place of Presentation
      Pusan, KOREA
    • Year and Date
      2015-08-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Wide-field heterodyne en-face OCT system for vibration measurement of internal surfaces2015

    • Author(s)
      S. Choi, F. Nin, T. Suzuki, and H. Hibino
    • Organizer
      CLEO-PR 2015
    • Place of Presentation
      Pusan, Korea, International convention center
    • Year and Date
      2015-08-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内部振動の可視化を目指した多波長走査型en -faceOCTシステムの開発2015

    • Author(s)
      崔森悦、鈴木孝昌
    • Organizer
      第55回 光波センシグ技術研究会
    • Place of Presentation
      東京理科大学 神楽坂キャンパス 森戸記念館
    • Year and Date
      2015-06-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Full-field step profile measurement with sinusoidal wavelength scanning interferometer2014

    • Author(s)
      Samuel Choi, Osami Sasaki, Takamasa Suzuki.
    • Organizer
      Proc. SPIE 9110, Dimensional Optical Metrology and Inspection for Practical Applications III, 91100F (28 May 2014)
    • Place of Presentation
      Baltimore, Maryland, USA.
    • Year and Date
      2014-05-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Low-coherence interferometer using a pulsation laser diode2014

    • Author(s)
      Takamasa Suzuki, Yusuke Ueno, Samuel Choi, Osami Sasaki.
    • Organizer
      SPIE 9110, Dimensional Optical Metrology and Inspection for Practical Applications III, 911009 (28 May 2014)
    • Place of Presentation
      Baltimore, Maryland, USA.
    • Year and Date
      2014-05-28
    • Related Report
      2014 Research-status Report
  • [Remarks] 研究内容(鈴木・崔研究室HP)

    • URL

      http://optlab.eng.niigata-u.ac.jp/res.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 研究内容

    • URL

      http://optlab.eng.niigata-u.ac.jp/res.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 平面振動計測装置及び平面振動計測方法2015

    • Inventor(s)
      崔森悦
    • Industrial Property Rights Holder
      崔森悦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-116904
    • Filing Date
      2015-06-09
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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