Calcium Phosphate Biomineralization in High Robustness Hydrogel
Project/Area Number |
26820300
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Composite materials/Surface and interface engineering
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 高強度ハイドロゲル / バイオセラミックス / ハイドロキシアパタイト / ソフトセラミックス / 骨形成 / 骨再生 / 骨接着 / タフハイドロゲル / 有機・無機複合材料 / バイオミネラリゼーション / 人工軟骨 / 有機無機複合材料 / ハイドロゲル |
Outline of Final Research Achievements |
Taking advantage of low frictional nature of robust & tough double network (DN) hydrogels, the application for artificial cartilage and scaffold of cartilage regeneration have been expected. However, due to the water like surface of the gel based on its high water content, any glues never fix gel in vivo efficiently. Inspired that natural soft supporting tissues (cartilages, ligaments and tendons) directly and strongly connect with bone tissues, bonding to bone of DN gel was carried out. hydroxyapatite (HAp), which is main inorganic component of bone and possess osteoconduction, was coated on the surface of DN gel, and the HAp/DN gel was implanted in rabbit bone defect. For 4 weeks after implantation, HAp/DN gel robustly bonded to bone because osteogenesis penetrated into permeable DN gel matrix. This overlapped region is a kind of interpenetrating structure, so that the robust fixation of DN gel was achieved.
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Report
(4 results)
Research Products
(205 results)
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[Journal Article] Double Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration2016
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Md. Tariful Islam Mredha, Xi Zhang, Takayuki Kurokawa, Tasuku Nakajima, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
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Journal Title
Advanced Materials
Volume: 印刷中
Issue: 31
Pages: 6740-6745
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Double network hydrogels strongly bondable to bones by spontaneous osteogenesis penetration2016
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Md. Tariful Islam Mredha, Xi Zhang, Takayuki Kurokawa, Tasuku Nakajima, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
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Journal Title
Advanced Materials
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Self-Adjustable Adhesion of Polyampholyte Hydrogels2015
Author(s)
Chanchal Kumar Roy, Honglei Guo, Tao Lin Sun, Abu Bin Ihsan, Takayuki Kurokawa, Masakazu Takahata, Takayuki Nonoyama, Tasuku Nakajima, Jian Ping Gong
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Journal Title
Advanced Materials
Volume: 27
Issue: 45
Pages: 7344-7348
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Robust Bonding of Tough Double Network Hydrogel to Bone2017
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Takayuki Kurokawa, Tasuku Nakajima, Kazunori Yasuda, Jian Ping Gong
Organizer
APS March Meeting 2017
Place of Presentation
Ernest N. Morial Convention Center, New Orleans, LA, USA
Year and Date
2017-03-13
Related Report
Int'l Joint Research
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[Presentation] The counter-ion condensation behavior of linear polyelectrolyte polymers and polyelectrolyte gels2017
Author(s)
Hongeli Guo, Takayuki Kurokawa, Masakazu Takahata, Wei Hong, Yoshinori Katsuyama, Yiwan Huang, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Organizer
APS March Meeting 2017
Place of Presentation
Ernest N. Morial Convention Center, New Orleans, LA, USA
Year and Date
2017-03-13
Related Report
Int'l Joint Research
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[Presentation] Ultrathin and tough physical hydrogels film with double network structure2017
Author(s)
Yanan Ye, Huijie Zhang, Tao Lin Sun, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Hiroyuki Ishitobi, Osamu Ito, Jian Ping Gong
Organizer
GelSympo2017
Place of Presentation
Nihon University Tsudanuma Campus, Chiba, Narashino
Year and Date
2017-03-07
Related Report
Int'l Joint Research
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[Presentation] Novel hydrogels based on H-bonds as reversible sacrificial bonds: tough, self-healing and thermal response behavior2017
Author(s)
Liang Chen, Tao Lin Sun, Kunpeng Cui, Daniel R. King, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
Organizer
GelSympo2017
Place of Presentation
Nihon University Tsudanuma Campus, Chiba, Narashino
Year and Date
2017-03-07
Related Report
Int'l Joint Research
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[Presentation] Amphiphilic Monomer to Fabricate High Functional Hydrogel2016
Author(s)
Md. Anamul Haque, Kei Mito, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Organizer
IPC2016 (The 11th SPSJ International Polymer Conference)
Place of Presentation
Fukuoka International Congress Center, Fukuoka, Fukuoka
Year and Date
2016-12-13
Related Report
Int'l Joint Research
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[Presentation] Tough Hydrogel Bondable to Bone by Osteogenesis Penetration2016
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Takayuki Kurosawa, Tasuku Nakajima, Kazunori Yasuda, Jian Ping Gong
Organizer
3rd International Conference on Biomaterials Science (ICBS2016)
Place of Presentation
Ito Hall at the university of Tokyo, Tokyo, Bunkyo-ku
Year and Date
2016-11-28
Related Report
Int'l Joint Research
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[Presentation] Novel Bonding of Tough Hydrogel to Bone by Osteogenesis Penetration2016
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Takayuki Kurokawa, Tasuku Nakajima, Kazunor Yasuda, Jian Ping Gong
Organizer
Bioceramics 28 (The 28th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
Place of Presentation
Charlotte, North Carolina, USA
Year and Date
2016-10-18
Related Report
Int'l Joint Research
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[Presentation] In Vivo Osteoconductive Property of HAp Composite Tough DN Hydrogel2016
Author(s)
Kiyama Ryuji, Nonoyama Takayuki, Wada Susumu, Kitamura Nobuto, Kurokawa Takayuki, Nakajima Tasuku, Yasuda Kazunori, Gong Jian Ping
Organizer
Bioceramics 28 (The 28th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
Place of Presentation
Charlotte, North Carolina, USA
Year and Date
2016-10-18
Related Report
Int'l Joint Research
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[Presentation] Anisotropic Hydroxyapatite Growth in Elongated Hydrogels2016
Author(s)
Kazuki Fukao, Takayuki Nonoyama, Takayuki Kurokawa, Tasuku Nakajima, Jian Ping Gong
Organizer
Bioceramics 28 (The 28th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
Place of Presentation
Charlotte, North Carolina, USA
Year and Date
2016-10-18
Related Report
Int'l Joint Research
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[Presentation] Bioadhesion of Polyampholyte Hydrogels2016
Author(s)
Chanchal Kumar Roy, Honglei Guo, Tao Lin Sun, Abu Bin Ihsan, Takayuki Kurokawa, Takayuki Nonoyama, Tasuku Nakajima, Jian Ping Gong
Organizer
第67回コロイドおよび界面化学討論会
Place of Presentation
北海道教育大学旭川校、北海道、旭川市
Year and Date
2016-09-22
Related Report
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[Presentation] 微粒子ゲルの摩擦低減効果2016
Author(s)
福田泰記、黒川孝幸、中島祐、野々山貴行、グン剣萍
Organizer
第27回高分子ゲル研究討論会
Place of Presentation
東京大学(東京都文京区)
Year and Date
2016-01-18
Related Report
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[Presentation] Novel Designing of Next-generation Biomaterials2016
Author(s)
Md. Tariful Islam Mredha, Xi Zhang, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Tasuaki Takagi, Jian Ping Gong
Organizer
北大若手研究者の会第16回研究交流会(The 16th Meeting for Young Researchers in Hokkaido University)
Place of Presentation
北海道大学フロンティア応用科学研究棟、北海道、札幌市
Related Report
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[Presentation] A Novel Double-Network Hydrogel Directly Bondable to the Bone and Its Application to Fixation of Artificial Cartilage and Ligament2015
Author(s)
Takayuki Nonoyama, Susumu Wada, Ryuji Kiyama, Nobuto Kitamura, Md. Tariful Islam Mredha, Xi Zhang, Takayuki Kurokawa, Tasuku Nakajima, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
Organizer
Pacifichem2015
Place of Presentation
Hawaii (USA)
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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[Presentation] Self- Adjustable Adhesion of Polyampholyte Hydrogels2015
Author(s)
Chanchal Kumar ROY, Hong Lei GUO, Tao Lin SUN, Abu Bin IHSAN, Takayuki NONOYAMA, Tasuku NAKAJIMA, Takayuki KUROKAWA, Jian Ping GONG
Organizer
Engineering Neo-Biomimetics VI
Place of Presentation
Shimadzu Corporation(京都府京都市)
Year and Date
2015-10-22
Related Report
Int'l Joint Research
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[Presentation] Tough physical double network hydrogels based on amphiphilic tri-block copolymer2015
Author(s)
Huijie Zhang, Tao Lin Sun, Yumihiko Ikura, Aokai Zhang, Xufeng Li, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Osamu Ito, Hiroyuki Ishitobi, Jian Ping Gong
Organizer
ゲルワークショップイン仙台
Place of Presentation
La楽リゾートホテル グリーン(宮城県仙台市)
Year and Date
2015-09-17
Related Report
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[Presentation] Polyampholyte hydrogels as wet adhesive2015
Author(s)
Chanchal Kumar Roy, Hong Lei Guo, Abu Bin Ihsan, Tao Lin Sun, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
Organizer
ゲルワークショップイン仙台
Place of Presentation
La楽リゾートホテル グリーン(宮城県仙台市)
Year and Date
2015-09-17
Related Report
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[Presentation] Tough physical double network hydrogels based on amphiphilic tri-block copolymer2015
Author(s)
Huijie Zhang, Tao Lin Sun, Yumihiko Ikura, Aokai Zhang, Xufeng Li, Tasuku Nakajima, Takayuki Nonoyama, Takayuki Kurokawa, Osamu Ito, Hiroyuki Ishitobi, Jian Ping Gong
Organizer
第64回高分子討論会
Place of Presentation
東北大学(宮城県仙台市)
Year and Date
2015-09-15
Related Report
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[Presentation] Fabrication of Tough Hydrogel Fiber2015
Author(s)
Masanori Okada, Ken-ichi Hoshino, Tao Lin Sun, Takayuki Kurokawa, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Organizer
Japan-Taiwan Bilateral Polymer Symposium
Place of Presentation
Hokkaido University(北海道札幌市)
Year and Date
2015-09-03
Related Report
Int'l Joint Research
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[Presentation] Bioadhesion Using Polyampholyte Hydrogel2015
Author(s)
Chanchal Kumar ROY, Abu Bin IHSAN, Tao Lin SUN, Takayuki NONOYAMA, Tasuku NAKAJIMA, Takayuki KUROKAWA, and Jian Ping GONG
Organizer
第64回高分子学会年次大会
Place of Presentation
札幌コンベンションセンター(北海道札幌市)
Year and Date
2015-05-27
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[Presentation] Biomechanical Evaluations Of A Novel Hydroxyapatite-coated PAMPS/PDMAAm Double-network Hydrogel As A Potential Artificial Cartilage Having Adhesive Ability To The Bone2015
Author(s)
Susumu Wada, Nobuto Kitamura, Takayuki Nonoyama, Shingo Semba, Jun Onodera, Yasuyuki Kawaguchi, Masashi Yokota, Kotaro Higa, Ryuji Kiyama, Takayuki Kurokawa, Jian Ping Gong, Kazunori Yasuda
Organizer
Orthopaedic Reserach Society 2015 Annual Meeting
Place of Presentation
MGM Grand, Las Vegas, USA
Year and Date
2015-03-28 – 2015-03-31
Related Report
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[Presentation] ゲル内部における剛直性高分子電解質の超構造形成2015
Author(s)
高橋 陸, Wu Zi Liang, Md.Arifuzzaman, 野々山 貴行, 中島 祐, 黒川 孝幸, グン 剣萍
Organizer
化学系学協会北海道支部2015年冬季研究発表会
Place of Presentation
北海道大学フロンティア応用科学研究棟(札幌市)
Year and Date
2015-01-28
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[Presentation] Tuning Adhesion of Hydrogel with Anisotropic Fiber Alignment2014
Author(s)
Chanchal Kumar Roy, Md. Tariful Islam Mredha, Yiwan Huang, Abu Bin Ihsan, Tao Lin Sun, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
Organizer
Joint symposium of the Polymer Network Group Meeting and the Gel Symposium (PN&G 2014, Tokyo)
Place of Presentation
Ito International Research Center, The University of Tokyo
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Developing anisotropic tough hydrogel from swim bladder collagen2014
Author(s)
Md. Tariful Islam Mredha, Xi Zhang, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Yasuaki Takagi, Jian Ping Gong
Organizer
Joint symposium of the Polymer Network Group Meeting and the Gel Symposium (PN&G 2014, Tokyo)
Place of Presentation
Ito International Research Center, The University of Tokyo
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Time Dependent Deformation of Tough Polyampholyte Hydrogels2014
Author(s)
Sadia Nazneen Karobi, Takayuki Kurokawa, Taolin Sun, Abu Bin Ihsan, Tasuku Nakajima, Takayuki Nonoyama, Jian Ping Gong
Organizer
Joint symposium of the Polymer Network Group Meeting and the Gel Symposium (PN&G 2014, Tokyo)
Place of Presentation
Ito International Research Center, The University of Tokyo
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Polyampholyte Hydrogel for Topical Skin Adhesive2014
Author(s)
Chanchal Kumar Roy, Abu Bin Ihsan, Tao Lin Sun, Takayuki Nonoyama, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong
Organizer
5th World Congress on Adhesion and Related Phenomena (WCARP-V)
Place of Presentation
Nara Prefectural New Public Hall, Nara
Year and Date
2014-09-07 – 2014-09-11
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[Presentation] 高強度ダブルネットワークゲル内部における剛直性高分子の超構造形成2014
Author(s)
高橋陸, Wu Zi Liang, Md.Arifuzzaman, 野々山貴行, 中島祐, 黒川孝幸, グン剣萍
Organizer
29th Summer University in Hokkaido・2014 年度北海道高分子若手研究会
Place of Presentation
定山渓ビューホテル(札幌市南区)
Year and Date
2014-08-29 – 2014-08-30
Related Report
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