| Project/Area Number |
26820300
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 高強度ハイドロゲル / バイオセラミックス / ハイドロキシアパタイト / ソフトセラミックス / 骨形成 / 骨再生 / 骨接着 / タフハイドロゲル / 有機・無機複合材料 / バイオミネラリゼーション / 人工軟骨 / 有機無機複合材料 / ハイドロゲル |
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| Outline of Final Research Achievements |
Taking advantage of low frictional nature of robust & tough double network (DN) hydrogels, the application for artificial cartilage and scaffold of cartilage regeneration have been expected. However, due to the water like surface of the gel based on its high water content, any glues never fix gel in vivo efficiently. Inspired that natural soft supporting tissues (cartilages, ligaments and tendons) directly and strongly connect with bone tissues, bonding to bone of DN gel was carried out. hydroxyapatite (HAp), which is main inorganic component of bone and possess osteoconduction, was coated on the surface of DN gel, and the HAp/DN gel was implanted in rabbit bone defect. For 4 weeks after implantation, HAp/DN gel robustly bonded to bone because osteogenesis penetrated into permeable DN gel matrix. This overlapped region is a kind of interpenetrating structure, so that the robust fixation of DN gel was achieved.
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