| Project/Area Number |
26820304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
Obata Akiko 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40402656)
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| Research Collaborator |
MIZUNO Toshihisa
IWANAGA Norihiko
IGUCHI Makito
OZEKI Yuto
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオマテリアル / 有機無機ハイブリッド / 不織布 / 生分解性 / タンパク質担持 |
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| Outline of Final Research Achievements |
Organic/inorganic hybrid fibre mats which have biodegradability and cell compatibility were developed for the use in tissue regeneration. The fibre mats were synthesized using water as a solvent, which can contribute to their eco-friendly synthesis, excellent safety for application to biomaterials, and original ability of encapsulating proteins and drugs without their denaturation. For example, the enzymic proteins which are encapsulated in the fibres could exhibit their enzymic activity and are protected from denaturation or degradation by protease in surroundings since they exist inside of the fibres and hybrid structures of the fibres keep such protease away from them. This is because molecule penetration into the hybrid structures possesses molecular-size dependence; no big molecules, such as proteases, can migrate into inside of the fibres.
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