Tissue adhesive using quinone-crosskinked gelatin
| Project/Area Number |
26820324
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural/Functional materials
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| Research Institution | Osaka Municipal Technical Research Institute |
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Principal Investigator |
YAMAUCHI Asao 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究主任 (80416304)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 接着タンパク質 / ポリフェノール / 酸化 / キノン / ゼラチン / 耐水 / 耐水接着性 |
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| Outline of Final Research Achievements |
The gelatin adhesive was improved by conjugating tyrosinase-catalyzed oxidation of phenolic compounds. The gelatin protein molecules were covalently crosslinked by the phenol oxidation products, the quinones, to form an insoluble polymeric substance. Indeed, the crosslinked adhesive using a natural polyphenol, caffeic acid, remarkably enhanced moisture resistance and waterproof property. The present quinone crosslinking reaction hence may be potentially useful for fabricating new formaldehyde-free gelatin glue for tissue.
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Report
(4 results)
Research Products
(17 results)
