| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Multicellular 3D cancer spheroid was fabricated as a tumor model using MKN74 human gastric cancer cells. Penetration behavior of model nanoparticles, hyaluronan nanogels incorporating anti-cancer drug cisplatin, into tumor spheroid was successfully visualized. It was found that the penetration ability of hyaluronan nanogels was significantly higher than that of their linear analog, suggesting the importance of the shape of drug nanocarriers. Furthermore, a mathematical model based on reaction-diffusion equation was proposed to describe the penetration behavior of nanoparticles. The model calculation fitted the experimental results well.
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