| Project/Area Number |
26830001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tohoku University |
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Principal Investigator |
Egawa Ryo 東北大学, 生命科学研究科, 助教(研究特任) (20722226)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | シナプス除去 / コネクトミクス / シナプス接着分子 / ニワトリ胚 / 杯状シナプス / シナプス前終末 / 発達期回路再編 / 軸索間競合 / 発達期再編 / N-カドヘリン / Neurexin |
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| Outline of Final Research Achievements |
During later developmental stages of both central and peripheral nervous systems, axonal branches and synapses are massively reorganized to form mature connections.
Here, we established the experimental system to approach the mechanisms of synapse elimination during development using chick ciliary ganglion, a conventional model system of synaptic development. We found that the maturation of presynaptic terminal from bouton-type to calyx-type started during E8-10. The excess axonal branches were pruned especially during E10-12. Consequently, axonal morphology converged to a homogeneous pattern of one-to-one connection at E14. This reorganization was influenced by the manipulation of presynaptic adhesion molecular, indicating the contribution to neuronal circuit development.
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