| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Slow wave sleep is an indicator of sleep need, which mechanism has not yet been uncovered. We investigated single-unit activity of cortex from freely behaving mice to understand how neuronal activity and network of neurons change across waking and slow wave sleep. Activity of neurons showed rhythmic and synchronized activity during slow wave sleep and more bursting for excitatory neurons. In spite of the synchronisity, network of neurons was weaker in slow wave sleep than in waking. Combination of calsium imaging and modeling of unit activity showed that burst of neurons increase influx of calcium into cells. These results suggest that unit activity in cortex could be a good evaluation for calcium activity in cortex.
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