Gene expression analysis along the tonotopic axis of the chicken
| Project/Area Number |
26830011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
WATANABE DAI 京都大学, 医学研究科
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 音源定位 / トノトピー / 遺伝子発現 / 分子プロファイリング / 層状核 / 大細胞核 / 神経回路形成 / 形態形成 |
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| Outline of Final Research Achievements |
Neurons in the auditory pathway are topographically arranged by their response to different auditory frequencies. Although tonotopic organization is a fundamental structure for frequency processing, the molecular mechanisms of the tonotopic map formation are largely unknown. In this study, we analyzed the gene expression profiles of two brainstem regions, nucleus laminaris and nucleus magnocellularis, to identify genes that are differentially expressed along the tonotopic axis. As a result, more than hundred molecules expressed in frequency-dependent manner and the most enriched pathway was axon guidance. These data should be useful for understanding the molecular mechanisms of the tonotopic map formation.
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Report
(4 results)
Research Products
(1 results)
