| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
I performed time-lapse imaging of nuclear translocation during neuronal migration with a high-speed confocal microscope, in order to understand molecular mechanisms of neuronal migration. As a result, I found that the nucleus is deformed and rotated during neuronal migration. Moreover, molecular biological approaches suggested that force generated by microbule-based motor proteins drives both nuclear translocation and rotation of migrating neurons (submitting a manuscript for publication). On the other hand, I also performed traction force microscope analysis for migrating neurons and found traction force accompanied by nuclear translocation, which is generated by actomyosin contractile activity (preparing a manucscript).
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