| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In the postnatal brain, newly born neurons continue to migrate toward their final destinations, where they terminate their migration and differentiate into mature neurons. Migrating neurons show immature morphology with a single leading process, and maintain their migration in a saltatory manner. In contrast, the neuronal morphology during termination process of migration is still unknown. Here we studied the role of Sema3E-PlexinD1 signaling in the regulation of neuronal morphology during termination process of migration in the postnatal olfactory bulb (OB). During the termination process of migration, new neurons formed cellular protrusions branched from the leading process. Furthermore, Sema3E-PlexinD1 signaling controls migratory potential of new neurons by regulating protrusion formation, thereby contributing to their final positioning and function in the OB. Results indicate the importance of morphological regulation in migrating new neurons in OB development and function.
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