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Mechanisms of cortical lyer formation-why migrating neurons stop just beneath the marginal zone-

Research Project

Project/Area Number 26830015
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionWakayama Medical University

Principal Investigator

Katayama Kei-ichi  和歌山県立医科大学, 先端医学研究所, 講師 (20391914)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大脳皮質層形成 / 神経細胞移動 / 滑脳症 / 知的障害 / Lis1 / 神経回路網形成 / 子宮内胎児脳電気穿孔法
Outline of Final Research Achievements

Reelin plays essential roles in the neuronal migration and cortical layer formation. We generated monoclonal antibodies against Reelin receptors (ApoER2 and Vldlr) and examined their localization in the developing cerebral cortex. Vldlr is localized to the distal portion of leading processes in the marginal zone, whereas ApoER2 is mainly localized to neuronal processes and the cell membranes of multipolar cells in the multipolar cell accumulation zone. These different expression patterns may contribute to the distinct actions of Reelin on migrating neurons during both the early and late migratory stages in the developing cerebral cortex.
Pafah1b1 is one of the downstream molecules of the Reeling signaling. We found that enhanced expression of Pafah1b1 in radially migrating neurons resulted in their over-migration into the marginal zone. Layer distribution of Pafaha1b1-overexpressed neurons shifted more superficially than control neurons.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Reelin receptors ApoER2 and VLDLR are expressed in distinct spatio-temporal patterns in developing mouse cerebral cortex.2014

    • Author(s)
      Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto TT and Nakajima K
    • Journal Title

      J. Comp. Neurol

      Volume: 523(3) Issue: 3 Pages: 463-78

    • DOI

      10.1002/cne.23691

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 大脳皮質の移動神経細胞にPafah1b1を過剰発現すると辺縁帯直下で移動を停止することなく辺縁帯内へと侵入する2016

    • Author(s)
      片山圭一、林周宏、坂口和成、仲嶋一範
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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