Revelation of the induction mechanism of plasticity during motor learning with the two-photon imaging and optical manipulation
| Project/Area Number |
26830020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | The University of Tokyo (2016)
National Institute for Basic Biology (2014-2015) |
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Principal Investigator |
MASAMIZU Yoshito 東京大学, 大学院医学系研究科(医学部), 助教 (90608530)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ２光子イメージング / 2光子励起顕微鏡 / 運動学習 / アデノ随伴ウイルス / 逆行性感染 / 2光子カルシウムイメージング |
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| Outline of Final Research Achievements |
First, fluorescence calcium sensor was expressed in only corticostriatal neurons or corticospinal neurons of mouse primary motor cortex by the retrograde gene transfer of adeno-associated virus. Next, I performed two-photon calcium imaging during a self-initiated lever-pull task for two weeks. These imaging data revealed that, during motor learning, the population which increased firing rate in corticostriatal neurons was different from that in corticospinal neurons.
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Report
(4 results)
Research Products
(4 results)
