| Project/Area Number |
26830021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
Hira Riichiro 基礎生物学研究所, 光脳回路研究部門, 助教 (80712299)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ブレインマシーンインターフェース / ２光子イメージング / 光遺伝学 / 2光子イメージング / 運動野 / BMI / オプトジェネティクス / 随意制御 |
|---|
| Outline of Final Research Achievements |
In this study, we developed several new methods including a real time analysis system of images obtained by two photon calcium imaging of cortical neurons and an experimental system that allowed us to simultaneously conduct two photon imaging and the optogenetic stimulation. We found that the reward timing dependent bidirectional modulation (RTBM) of cortical neurons during the learning of the single neuron operant conditioning. The RTBM might be one of the key mechanism that enables animal to learn to use brain machine interface.
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