Neural circuit mechanisms generating prediction error coding to control adaptive fear learning
| Project/Area Number |
26830023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Ozawa Takaaki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 客員研究員 (90625352)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 恐怖記憶 / 扁桃体 / 中脳水道周囲灰白質 / 条件づけ |
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| Outline of Final Research Achievements |
For adaptive behavioral decision making, the strength of aversive learning needs to be appropriate to the level of danger. During auditory fear conditioning, learning finally reaches a steady state at a certain memory strength (termed the learning asymptote) beyond which further training is ineffective at producing learning. However, it is poorly understood how our brains set this fear learning asymptote. In this study, we found that (1) central nucleus of amygdala to ventrolateral periaqueductal gray pathway is activated by auditory stimulus predicting aversive outcome during fear conditioning to suppress response to aversive stimulus in lateral nucleus of amygdala, which is known as fear memory storage area. (2) This pathway further activates ventrolateral periaqueductal gray to rostroventral medulla pathway to set fear learning asymptote. Our findings give new insight into the neural mechanism of anxiety disorders which is typified by exaggerated fear learning.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation.2014
Author(s)
Johansen JP, Diaz-Mataix L, Hamanaka H, Ozawa T, Ycu E, Koivumaa J, Kumar A, Hou M, Deisseroth K, Boyden ES, LeDoux JE
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 111
Issue: 51
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Presentation] 扁桃体-中脳水道周囲灰白質回路は恐怖記憶の強さを制御する2014
Author(s)
Takaaki Ozawa, Edgar A. Ycu, Touqeer Ahmed, Ashwani Kumar, Jenny Koivumaa, Joshua P. Johansen
Organizer
平成26年度 生理学若手研究者フォーラム
Place of Presentation
東京女子医大（東京，新宿）
Year and Date
2014-07-26
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