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Mechanism of activity dependent morphological change of dendrites in mammalian cortex

Research Project

Project/Area Number 26830024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Matsui Asuka  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (30599684)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords樹状突起 / バレル / 神経活性依存的 / 大脳皮質 / バレル皮質 / 子宮内電気穿孔法 / 初代神経細胞培養
Outline of Final Research Achievements

We previously reported that BTBD3 (BTB/POZ domain containing 3) is essential for dendrite patterning of spiny stellate neurons in mouse somatosensory barrel cortex. Dendrites with less input are removed by BTBD3, however, dendrites with higher input were resistant for BTBD3 dependent dendrite elimination. This suggests that BTBD3 determines dendrite specificity for removal/maintenance through sensing the difference of neuronal inputs. However, it remains unknown how BTBD3 senses neuronal inputs and controls dendrite morphology. This present study revealed that BTBD3 phosphorylation triggers Rho activation through BTBD3-plexin interaction. We also found that neuronal activity induces BTBD3 translocation to intermediate filaments, suggesting that BTBD3 binding to intermediate filaments stabilizes these high input dendrites even more. These results suggest that the different state of BTBD3 determines dendrite specificity for removal/maintenance.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015

All Presentation (7 results) (of which Invited: 2 results) Book (1 results)

  • [Presentation] Selective dendrite removal/maintenance is controlled by activity dependent BTBD3 protein status2016

    • Author(s)
      松居 亜寿香
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜)
    • Year and Date
      2016-07-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Translocation of BTBD3 protein status controls proper dendrite development2016

    • Author(s)
      松居 亜寿香
    • Organizer
      神経発生討論会
    • Place of Presentation
      東京医科歯科大学(東京・御茶ノ水)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Neuronal activity dependent translocation of BTBD3 to the cytoskeleton is essential for proper dendrite development2015

    • Author(s)
      松居 亜寿香
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Neuronal activity dependent translocation of Btbd3 to the cytoskeleton is essential for proper dendrite development2015

    • Author(s)
      松居 亜寿香
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Neuronal activity dependent translocation of BTBD3 to the cytoskeleton is essential for proper dendrite development2015

    • Author(s)
      松居 亜寿香
    • Organizer
      Neuronal circuits, Development and plasticity of the early visual system
    • Place of Presentation
      神戸ポートピアホテル(兵庫・神戸)
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Neuronal activity dependent translocation of Btbd3 to the cytoskeleton is essential for proper dendrite development2015

    • Author(s)
      松居 亜寿香
    • Organizer
      Neuronal circuits, Development and plasticity of the early visual system
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2015-07-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 神経活性依存的なBTBD3の細胞骨格への移行は適切な樹状突起の発達に重要である2015

    • Author(s)
      松居 亜寿香
    • Organizer
      第8回神経発生討論会
    • Place of Presentation
      九州大学
    • Year and Date
      2015-03-19 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Book] こころの科学増刊「ここまでわかった!脳とこころ」2016

    • Author(s)
      松居亜寿香
    • Total Pages
      4
    • Publisher
      日本評論社
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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