Cellular mechanisms of vascular remodeling for homeostasis in the sensory circumventricular organs
Project/Area Number |
26830029
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Nara Medical University |
Principal Investigator |
Morita Shoko 奈良県立医科大学, 医学部, 助教 (70647049)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 血液脳関門 / ホメオスタシス / 血管新生 / 炎症 / 恒常性維持 / 血管透過性 / 免疫 |
Outline of Final Research Achievements |
The sensory circumventricular organs (CVOs), which comprise the organum vasculosum of the lamina terminalis, the subfornical organ and the area postrema, lack a typical blood-brain barrier and monitor directly blood-derived information to regulate body fluid homeostasis, inflammation, feeding, nausea and vomiting. Until now, almost nothing has been documented about vascular features of the sensory CVOs except fenestration of vascular endothelial cells. I demonstrated that continuous angiogenesis occurs in the adult sensory CVOs. My data indicate that continuous angiogenesis is dependent on vascular endothelial growth factor signaling and responsible for the dynamic plasticity of vascular structure and permeability.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Heterogenous vascular permeability and alternative diffusion barrier in the sensory circumventricular organs of adult mouse brain2015
Author(s)
Morita, S, Furube, E, Mannari, T, Okuda, H, Tatsumi, K, Wanaka, A, Miyata, S
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Journal Title
Cell and Tissue Research
Volume: 0
Issue: 2
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain2015
Author(s)
Nakano, Y, Furube, E, Morita, S, Wanaka, A, Nakashima, T, Miyata, S
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Journal Title
Journal of Neuroimmunology
Volume: 278
Pages: 144-158
DOI
Related Report
Peer Reviewed
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[Journal Article] Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain2015
Author(s)
Morita, S, Furube, E, Mannari, T, Okuda, H, Tatsumi, K, Wanaka, A, Miyata, S
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Journal Title
Cell and Tissue Research
Volume: 359
Issue: 3
Pages: 865-884
DOI
Related Report
Peer Reviewed
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[Presentation] 脳弓下器官の血管による免疫応答時の物質透過制限2014
Author(s)
森田 晶子, 中原 一貴, 辰巳 晃子, 奥田 洋明, 蓬莱 敦, 宮田 清司, 和中 明
Organizer
第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
Place of Presentation
奈良市
Year and Date
2014-09-29 – 2014-10-01
Related Report
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