What is the reason why subplate neurons die selectively.

Research Project

Project/Area Number	26830033
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Nerve anatomy/Neuropathology
Research Institution	Tokyo Metropolitan Institute of Medical Science
Principal Investigator	HIRAI Shinobu 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (00625189)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	サブプレートニューロン / 神経発生
Outline of Final Research Achievements	It is known that the numbers of subplate neurons (SPn) have variety in some diseases. It's decreasing in Alzheimer's disease and increasing in Autism and Schizophrenia. We tried to confirm that the brain function might be changed depending on the number of SPn. We established how to induce the target genes to SPn specifically. In particular, we injected adeno-associated Virus (type 9) into the fetus ventricle to express target genes. Using this systems, we are analyzing the histological and behavioral changes of brain function associated with the number of SPn.

Report

(3 results)