| Project/Area Number |
26830034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
Nobusawa Sumihito 群馬大学, 医学(系)研究科(研究院), 助教 (80635318)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 胎児性脳腫瘍 / 多層性ロゼット |
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| Outline of Final Research Achievements |
Ependymoblastomas, embrynal tumors with abundant neuropil and true rosettes (ETANTR) and medulloepitheliomas are subtypes of central nervous system primitive neuroectodermal tumors. Recent data suggest that these tumors constitute a single entity, embryonal tumors with multilayered rosettes (ETMR), for which 19q13.42 amplification represents a specific molecular hallmark, and that LIN28A is a specific immunohistochemical marker for ETMR. We analyzed LIN28A immunohistochemical expression in ETMR and their histological mimics with multilayered rosettes, atypical teratoid/rhabdoid tumors (AT/RT), immature teratomas and anaplastic ependymomas, and found that LIN28A can be used for differentiation between ETMR and anaplastic ependymomas but is not useful for differentiation of ETMR from AT/RT and immature teratomas.
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