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Analysis of microglial polarization switching.

Research Project

Project/Area Number 26830040
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNara Medical University (2016)
Asahikawa Medical College (2014-2015)

Principal Investigator

Tanaka Tatsuhide  奈良県立医科大学, 医学部, 講師 (80567032)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsミクログリア / IRF7 / microglia / ATF3 / polarization
Outline of Final Research Achievements

Microglia are generally considered the immune cells of the central nervous system. Recent studies have demonstrated that under specific polarization conditions, microglia develop into two different phenotypes, termed M1-like and M2-like microglia. However, the phenotypic characteristics of M1-like- and M2-like-polarized microglia and the mechanisms that regulate polarization are largely unknown. We found that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo. Knockdown of IRF7 using siRNA suppressed the expression of M1 marker mRNA and reduced phosphorylation of STAT1. Our findings suggest that IRF7 signaling may play an important role in microglial polarization switching.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (10 results)

  • [Journal Article] Microglia support ATF3-positive neurons following hypoglossal nerve axotomy.2017

    • Author(s)
      Tanaka T, Murakami K, Bando Y, Nomura T, Isonishi A, Morita-Takemura S, Tatsumi K, Wanaka A, Yoshida S.
    • Journal Title

      Neurochemistry International

      Volume: 印刷中 Pages: 332-342

    • DOI

      10.1016/j.neuint.2017.05.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interferon regulatory factor 7 participates in the M1-like microglial polarization switch.2015

    • Author(s)
      Tanaka T, Murakami K, Bando Y, Yoshida S.
    • Journal Title

      GLIA

      Volume: 63 Issue: 4 Pages: 595-610

    • DOI

      10.1002/glia.22770

    • NAID

      120005766849

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 運動神経損傷後の神経細胞体周囲に集積するミクログリアの機能2017

    • Author(s)
      田中達英、村上公一、板東良雄、野村太一、石西綾美、森田-竹村晶子、辰巳晃子、和中明生、吉田成孝
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 舌下神経損傷後のミクログリアの機能2016

    • Author(s)
      田中達英、村上公一、野村太一、板東良雄、吉田成孝
    • Organizer
      第39回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 舌下神経損傷後に起こる活性化ミクログリアの機能2015

    • Author(s)
      田中達英、村上公一、野村太一、板東良雄、吉田成孝
    • Organizer
      第88回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 舌下神経損傷後に起こる活性化ミクログリアの機能2015

    • Author(s)
      田中達英、村上公一、野村太一、板東良雄、吉田成孝
    • Organizer
      第58回日本神経化学会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 舌下神経損傷後に起こる活性化ミクログリアの機能2015

    • Author(s)
      田中達英、村上公一、野村太一、板東良雄、吉田成孝
    • Organizer
      第38回日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経損傷後に神経細胞体周囲に集積する活性化ミクログリアの機能2015

    • Author(s)
      田中達英、村上公一、野村太一、板東良雄、吉田成孝
    • Organizer
      第52回日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2015-07-17
    • Related Report
      2015 Research-status Report
  • [Presentation] M1-likeミクログリアへの極性スイッチにはinterferon regulatory factor 7が関与する2015

    • Author(s)
      田中達英、村上公一、板東良雄、吉田成孝
    • Organizer
      日本解剖学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Interferon rgulatory factor 7 participates in the M2-like to M1-like microglial polarization switch.2015

    • Author(s)
      Tanaka T, Murakami K, Bando Y, Yoshida S.
    • Organizer
      Keystone symposia
    • Place of Presentation
      Taos, USA, USA
    • Year and Date
      2015-01-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Changes of microglial characters in response to extracellular stimulation.2014

    • Author(s)
      Tanaka T, Murakami K, Bando Y, Yoshida S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞外刺激に応じたミクログリアの機能変化2014

    • Author(s)
      田中達英、村上公一、板東良雄、吉田成孝
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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