Differential neurotrophic signals for the development of serotonergic neurons.
| Project/Area Number |
26830044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | セロトニン神経細胞 / 縫線核 / 栄養因子 / サリドマイド / FGF2 / BDNF / NRG1 / トリプトファン水酸化酵素 / チロシン水酸化酵素 / セロトニン神経 / FGF / GDNF |
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| Outline of Final Research Achievements |
Monoamine such as serotonin (5HT) and dopamine (DA) is a key modulator of brain development and functions. Recent studies also indicate the implication in the etiology or neuropathology of various brain diseases such as schizophrenia and autism. In early developmental stage, progenitors of both 5HT and DA neurons are located in the mid-hindbrain boundary. Of note, neurotrophic factors such as BDNF, GDNF and FGF2 show distinct trophic activities on 5HT and DA neuronal populations. However, the selectivity and the strength of each neurotrophic factor remains to be characterized for 5HT and DA neurons. Here we examined trophic features of growth factors in rat rhombencephalon cultures.
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Report
(3 results)
Research Products
(2 results)
