| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
From our analyses of innate immune TRIF-pathway deficiency and increase or decrease in number of specific infiltrating immune cells in ALS model mice, it was suggested that the induction of cell-death in dysmorphic activated astrocytes was regulated by not immune cell mediated Fas-pathway but cell-autonomous TRIF-pathway in ALS model mice. Meanwhile, from comparative analyses between two strains of ALS model mice that have distinct genetic backgrounds in peripheral immune responses, we found that the peripheral immune response might affect to a disease course and a microglia number in ALS model mice. These results suggest that peripheral immune system contributes to a disease course of ALS.
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