Analysis of molecular mechanisms of IP3R1-mediated maintenance of cerebellar synaptic circuits in adults.
| Project/Area Number |
26830051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Sugawara Takeyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (70584522)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小脳 / プルキンエ細胞 / スパイン / イノシトール３リン酸受容体 / 細胞骨格 / イノシトール3リン酸受容体 |
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| Outline of Final Research Achievements |
Dendritic spines of neurons are postsynaptic sites receiving excitatory inputs from neuronal axons. Maintenance of proper distribution and morphology of spines in neurons underlies critical aspects of brain functions. In this study, we found that Ca2+/calmodulin-dependent kinase II b isoform (CaMKIIb) was phosphorylated by protein kinase C (PKC) under type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) signaling in cerebellar Purkinje cells, and which was involved in controlling the maintenance of Purkinje cell spines in mature cerebellum.
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Report
(3 results)
Research Products
(1 results)
