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Analysis of molecular mechanisms of IP3R1-mediated maintenance of cerebellar synaptic circuits in adults.

Research Project

Project/Area Number 26830051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Sugawara Takeyuki  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (70584522)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小脳 / プルキンエ細胞 / スパイン / イノシトール3リン酸受容体 / 細胞骨格 / イノシトール3リン酸受容体
Outline of Final Research Achievements

Dendritic spines of neurons are postsynaptic sites receiving excitatory inputs from neuronal axons. Maintenance of proper distribution and morphology of spines in neurons underlies critical aspects of brain functions. In this study, we found that Ca2+/calmodulin-dependent kinase II b isoform (CaMKIIb) was phosphorylated by protein kinase C (PKC) under type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) signaling in cerebellar Purkinje cells, and which was involved in controlling the maintenance of Purkinje cell spines in mature cerebellum.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] IP3R1 regulates cerebellar circuits by maintaining the spine morphology of Purkinje cells in Adult Mice.2014

    • Author(s)
      Takeyuki Sugawara, Chihiro Hisatsune, Le Dinh Tung, Tsutomu Hashikawa, Moritoshi Hirono, Soichi Nagao and Katsuhiko Mikoshiba.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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