| Project/Area Number |
26830052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Hui Kai-Wan Kelvin 国立研究開発法人理化学研究所, 脳科学総合研究センター, 国際特別研究員 (70721843)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | proteomics / autism spectrum disorder / translation regulation / autism |
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| Outline of Final Research Achievements |
Recently, mouse models of many major forms of autism spectrum disorders (ASD) were shown to have abnormal protein synthesis. However, there has been no comprehensive studies to identify the proteins affected in ASD models. I have utilized a novel unbiased method to identify newly synthesized proteins after stimulation of normal and a common ASD model brain cells. Using this method, I have found that the proteins produced in response to stimulation include proteins required for chemical communication between brain cells and proteins mediating structural changes of the connections between brain cells. I have also identified that an increased number of proteins are produced by the ASD model brain cells. Interestingly, many of these were previously unknown. In future studies, I aim to examine how combination of ASD-related mutations affect proteins produced after stimulation as it was shown that two ASD-related mutations surprisingly could counteract and rescue ASD abnormalities in mice.
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