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The analysis of roles of C-type lectin receptors in commensal microbiota-mediated colitis development, tumorogenesis and host defence against bacteria-infection

Research Project

Project/Area Number 26830058
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionTokyo University of Science

Principal Investigator

TANG CE  東京理科大学, 研究推進機構生命医科学研究所, 助教 (00572166)

Research Collaborator IWAKURA Yoichiro  
KAKUTA Shigeru  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsC型レクチン / 腸内細菌叢 / サイトカイン / 遺伝子欠損マウス / C型レクチン
Outline of Final Research Achievements

The most remarkable achievement in this scientific research is that we found that a member belonging to innate immune C-type lectin receptor family is involved in the regulation of special commensal bacterial population and further influence the development of intestinal inflammation. As the C-type lectin receptor family member, Dectin-1 has been known as the receptor recognizing fungal cell wall component, beta-glucan. In this study, we found that mice deficient with Dectin-1 gene showed drastic suppression of colitis compared with wild-type mice, and this inhibition of intestinal inflammation was caused by over-expansion of commensal Lactobacillus-induced inflammation-suppressing T cells. Treating the mice with Dectin-1-blocade ligand dramatically ameliorated colitis, and these results were published on Cell Host & Microbe (Tang C. et al. 2015;18:183-97) followed by reporting news in Japan. This study suggests a totally new strategy for IBD therapy by targeting on Dectin-1 signaling.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (4 results) Remarks (1 results)

  • [Journal Article] 1.Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus- mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki, Shigeru Kakuta, Kenshiro Oshima, Masahira Hattori, Kozue Takeshita, Takanori Kanai, Shinobu Saijo and Yoichiro Iwakura
    • Journal Title

      Cell Host & Microbe

      Volume: 18 Issue: 2 Pages: 183-197

    • DOI

      10.1016/j.chom.2015.07.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 炎症性腸疾患と食物アレルギーの病態制御におけるDectin-1と短鎖βグルカンの役割の解析2017

    • Author(s)
      唐 策
    • Organizer
      2017糖鎖免疫研究会
    • Place of Presentation
      東京医科歯科大学M&Dタワー、東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A novel role of Dectin-1 signaling in controlling food antigen-induced mouse intestinal allergy2016

    • Author(s)
      唐 策
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine2016

    • Author(s)
      Ce Tang
    • Organizer
      International Congress of Immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamina, Yoichiro Iwakura
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS)
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸内細菌叢による炎症性腸疾患の制御におけるDectin-1の役割の解析2015

    • Author(s)
      唐 策
    • Organizer
      第24回内毒素・LPS研究会
    • Place of Presentation
      東京大学農学部中島董一郎記念ホール
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine2014

    • Author(s)
      Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki and Yoichiro Iwakura
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都府京都市国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Dectin-1シグナルを介するマウス腸管炎症の抑制による新規な腸疾患治療法開発2014

    • Author(s)
      唐 策、神谷 知憲、角木 基彦、大島 健志朗、服部 正平、岩倉 洋一郎
    • Organizer
      第61回日本実験動物学会
    • Place of Presentation
      北海道札幌市札幌コンベンショナルセンター
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Book] 《化学と生物》「セミナー室 腸内相互作用の理解に基づいた健康の増進・疾患の予防(2)低分子βグルカン摂取により炎症性腸疾患を予防,改善する 」2017

    • Author(s)
      唐策、角田茂、岩倉洋一郎
    • Total Pages
      7
    • Publisher
      国際文献社
    • Related Report
      2016 Annual Research Report
  • [Book] 《実験医学》「Current Topics デクチン1シグナルの阻害は、腸内乳酸桿菌を増殖させ、制御性T細胞を増加させることによって、大腸炎を抑制する」2016

    • Author(s)
      唐策、岩倉洋一郎
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Book] 《サイトカイン・増殖因子キーワード事典》 第一章 インターロイキン IV. その他の受容体を介して作用するサイトカイン 22. IL-23/352015

    • Author(s)
      唐 策、岩倉 洋一郎
    • Total Pages
      3
    • Publisher
      羊土社、ISBN 978-4-7581-2055-5
    • Related Report
      2015 Research-status Report
  • [Book] 《実験医学》 Current Topics デクチン1シグナルの阻害は、腸内乳酸桿菌を増殖させ、制御性T細胞を増加させることによって、大腸炎を抑制する2015

    • Author(s)
      唐 策、岩倉 洋一郎
    • Total Pages
      4
    • Publisher
      羊土社、ISBN 978-4-7581-0147-9
    • Related Report
      2015 Research-status Report
  • [Remarks] 低分子βグルカン摂取により炎症性腸疾患を予防、改善する

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2015/20150817-1.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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