| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Establishment of chimeric mice which were derived from lung cancer model, colon tumor model and OSKM-inducible ESCs. After the induction of tumorigenesis, we observed reporter expression in lung cancer and OSKM-inducible model. Moreover, we examined the expression of transposable element in EWS/ATF1-inducible mouse clear cell sarcoma cell lines. The expression level was increased in the absence of oncogene expression. This phenomenon was also observed in human cancer cells. So, we trying to establish the drug screening system which apply the retrotransposon expression to indicator for oncogene suppression.
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