Establishment of visualization system for cancer epigenome with 2C reporter
Project/Area Number |
26830069
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kyoto University |
Principal Investigator |
Semi Katsunori 京都大学, iPS細胞研究所, 研究員 (90633058)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | がん / エピジェネティクス / リプログラミング |
Outline of Final Research Achievements |
Establishment of chimeric mice which were derived from lung cancer model, colon tumor model and OSKM-inducible ESCs. After the induction of tumorigenesis, we observed reporter expression in lung cancer and OSKM-inducible model. Moreover, we examined the expression of transposable element in EWS/ATF1-inducible mouse clear cell sarcoma cell lines. The expression level was increased in the absence of oncogene expression. This phenomenon was also observed in human cancer cells. So, we trying to establish the drug screening system which apply the retrotransposon expression to indicator for oncogene suppression.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis.2015
Author(s)
Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
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Journal Title
Carcinogenesis
Volume: 36
Issue: 7
Pages: 719-29
DOI
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Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Book] 日本臨牀2015
Author(s)
八木正樹、蝉克憲、山田泰広
Total Pages
5
Publisher
がんとリプログラミング
Related Report
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[Book] 実験医学2014
Author(s)
蝉克憲、山田泰広
Total Pages
5
Publisher
リプログラミング技術を用いたがんエピゲノム研究
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