| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The tyrosine kinase Src regulates both normal physiological functions and cancer progression. However, the molecular mechanism of the spatiotemporal regulation of Src is not fully understood. In this study, we identified Rsp1 as a regulator of activated Src in the lipid rafts. In normal cells, Rsp1 coordinately controlled epithelial tubulogenesis through spatiotemporal regulation of the Src signaling pathway. Meanwhile, Rsp1 promoted invasiveness in cancer cells. These findings indicate that Rsp1 controls the diverse functions of Src through the spatiotemporal regulation of activated Src.
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