Molecular mechanism of the lipid raft-based oncogenic signal transduction
| Project/Area Number |
26830071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | Src / 脂質ラフト / 上皮管腔形成 / 浸潤 / がん / 上皮細胞 |
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| Outline of Final Research Achievements |
The tyrosine kinase Src regulates both normal physiological functions and cancer progression. However, the molecular mechanism of the spatiotemporal regulation of Src is not fully understood. In this study, we identified Rsp1 as a regulator of activated Src in the lipid rafts. In normal cells, Rsp1 coordinately controlled epithelial tubulogenesis through spatiotemporal regulation of the Src signaling pathway. Meanwhile, Rsp1 promoted invasiveness in cancer cells. These findings indicate that Rsp1 controls the diverse functions of Src through the spatiotemporal regulation of activated Src.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition2016
Author(s)
Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S, Oneyama C, Sabe H, Okada M.
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Journal Title
Oncogenesis
Volume: 5
Issue: 9
Pages: e258-e258
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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