| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Suppression of tumor angiogenesis suppress penetration of nutrients into tumor, resulting in tumor growth suppression. It is known that receptor tyrosine kinase Tie1 associates with vascular stabilization. In this study, we focused on the function of Tie1 ectodomain which is cleaved by angiogenic stimulation. We identified that Tie1 ectodomain suppresses pathological angiogenesis via direct interaction with endothelial cells in vitro and in vivo.
In the future, we hope to establish the induction method of Tie1 ectodomain shedding or regulation method of Tie1 ectodomain binding molecule in tumor vasculature.
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