| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
The epithelial-mesenchymal transition (EMT) contributes cancer progression. Although previous reports suggest that alternations in cell metabolism are characteristic of many tumor cells, the contribution of cancer metabolism to the morphological changes in EMT remains elusive.
To examine the roles for changed metabolism, we analyzed the metabolome of breast cancer cells before and after EMT using a gas-chromatography mass spectrometry. We found that metabolic profiling was dramatically changed during EMT. EMT resulted in increase in pyruvic acid and lactic acid and decrease in phosphoenolpyruvic acid, indicating the activation of glycolysis.
|
