Understanding metabolic regulation of epithelial-mesenchymal transition
Project/Area Number |
26830073
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kobe University |
Principal Investigator |
Irino Yasuhiro 神戸大学, 医学(系)研究科(研究院), 特命助教 (10415565)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 代謝 / がん / 上皮間葉転換 / がんの代謝 / メタボローム解析 |
Outline of Final Research Achievements |
The epithelial-mesenchymal transition (EMT) contributes cancer progression. Although previous reports suggest that alternations in cell metabolism are characteristic of many tumor cells, the contribution of cancer metabolism to the morphological changes in EMT remains elusive. To examine the roles for changed metabolism, we analyzed the metabolome of breast cancer cells before and after EMT using a gas-chromatography mass spectrometry. We found that metabolic profiling was dramatically changed during EMT. EMT resulted in increase in pyruvic acid and lactic acid and decrease in phosphoenolpyruvic acid, indicating the activation of glycolysis.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma2016
Author(s)
Hiroaki Nagashima, Kazuhiro Tanaka, Takashi Sasayama, Yasuhiro Irino, Naoko Sato, Yukiko Takeuchi, Katsusuke Kyotani, Akitake Mukasa, Katsu Mizukawa, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, and Eiji Kohmura
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Journal Title
Neuro-Oncology
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.2015
Author(s)
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
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Journal Title
J Clin Invest
Volume: 125
Issue: 4
Pages: 1591-602
DOI
Related Report
Peer Reviewed / Open Access