analysis of a new endogenous protein in endometrial cancer

• Project/Area Number: 26830084
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Osaka Medical College
• Principal Investigator: Tanaka Yoshimichi 大阪医科大学, 医学部, 助教 (10625502)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 子宮内膜細胞 / デコリン / プロゲステロン / ディナゲスト / 細胞周期 / 細胞外基質蛋白 / Decorin / ＥＭＴ / 子宮内膜症 / 子宮内膜癌 / 上皮間葉転換

Outline of Final Research Achievements

Decorin has been shown to be a powerful endogenous tumor repressor acting in a paracrine fashion to limit tumor growth. It was noted that progesterone and dienogest directly induced the binding of the decorin promoter.Progesterone and dienogest also led to significant induced cell cycle arrest via decorin by promoting production of p21. Ｄecorin induced by dienogest appears to play a
crucial role in suppressing endometriosis by exerting anti-proliferative　effects and inducing　cell cycle arrest via the production of p21 human ectopic endometrial cells and eutopic endometrial stromal cells.

Research Products

• [Journal Article] Estradiol-mediated hepatocyte growth factor is involved in the implantation of endometriotic cells via the mesothelial-to-mesenchymal transition in the peritoneum. (2015)
  • Author(s): Ono YJ, Hayashi M, Tanabe A, Hayashi A, Kanemura M, Terai Y, Ohmichi M.
  • Journal Title: Am J Physiol Endocrinol Metab. Volume: 308 Pages: 950-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The EMT (epithelial-mesenchymal-transition)-related protein expression indicates the metastatic status and prognosis in patients with ovarian cancer. (2014)
  • Author(s): Takai M, Terai Y, Kawaguchi H, Ashihara K, Fujiwara S, Tanaka T, Tsunetoh S, Tanaka Y, Sasaki H, Kanemura M, Tanabe A, Ohmichi M.
  • Journal Title: J Ovarian Res. Volume: ２７ Pages: 76-80
  • Peer Reviewed
• [Journal Article] Decorin induced by progesterone plays a crucial role in suppressing endometriosis. (2014)
  • Author(s): Ono YJ, Terai Y, Tanabe A, Hayashi A, Hayashi M, Yamashita Y, Kyo S, Ohmichi M.
  • Journal Title: J Endocrinol. Volume: ２２３ Pages: 203-216
  • Peer Reviewed