Identification of a responsible gene for multi step leukemogenesis of ATL by using the panel of ATL-derived cell lines.

Research Project

Project/Area Number	26830087
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology
Research Institution	Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Principal Investigator	INE SHOJI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 (80573683)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	成人T細胞白血病 / シグナル伝達 / ATL
Outline of Final Research Achievements	To identify critical factors for the onset of adult T cell leukemia (ATL), we fractionated the cell population showing high tumor-initiating ability in immune deficient NOG mice from ATL-derived cell lines.These cells also showed the up regulation of AKT and NF-kB signaling, which suggests the possible role of these signal transduction pathways in tumorigenicity of ATL cells. To reveal the responsible genes for up regulation of NF-kB signaling, we conducted functional screening using the NF-kB-reporter cell and could identify unreported genes which can modulate NF-kB signaling.

Report

(3 results)