| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We investigated the involvement of nervous and immune system interactions in development of colon cancer using a mouse model for colorectal and intestinal cancer.
MyD88 plays a central role in innate immunity. Loss of MyD88 function in intestinal epithelial cells, induced by tamoxifen administration, leaded to a reduction of the number of intestinal tumors in MyD88FL/FL; Apc; Villin-CreERT2 compound mutant mice. In addition, we found that several neuropeptide levels were changed in tumors developed in Apc mutant mice. Among them, expressions of five neuropeptides were affected by stimulation of mouse intestinal organoids with several cytokines. These results suggest that the possible involvement of nervous and immune system interactions in development of colon cancer.
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