| Project/Area Number |
26830092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Tanaka Hiroki 旭川医科大学, 医学部, 助教 (70596155)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 鉄過剰 / 肝癌 / 脂質代謝 / 鉄 / コレステロール合成 / エネルギー代謝 |
|---|
| Outline of Final Research Achievements |
In the iron-loaded mouse livers, genetic expression of metabolic enzymes involved in cholesterol biosynthesis, β oxidation and prenylation (Fdps, FTase) were increased. These metabolic pathways are known to modulate Ras proteins post-translationally. In mouse primary hepatocytes, although iron-induced 8OHdG production was neutralized in the presence of the anti-oxidant NAC, phosphorylation of ERK1/2 was not canceled even in the presence of NAC. However, the iron chelator, deferoxamine reduced iron-induced expression of Fdps, FTase and phospho-ERK1/2. These results clearly indicate that iron affects not only the production of oxidative damage but lipid metabolism, thereby promoting a proliferation signal in the liver.
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