Search of novel treatment and effect of prior treatment prediction based on Glycolytic activity in breast cancer.

• Project/Area Number: 26830093
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Tohoku University
• Principal Investigator: Sato-Tadano Akiko 東北大学, 大学病院, 助教 (50723912)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乳癌 / 解糖系亢進 / hexokinase / HIF-1α / 糖代謝 / PET / 解糖系 / 治療効果予測因子 / サブタイプ / 予後予測 / hexokinaseII / 3-bromopyruvate

Outline of Final Research Achievements

The purpose of this research　is investigation of significance ,treatment effect of Inhibitors and usefulness of PET based on Glycolytic activity in breast cancer.In the cell proliferation of carcinoma, increased glycolytic activity is one of the major features. In this study, the glycolytic activity plays important roles in low Proliferative capacity;Luiminal type breast cancer. Results of our present study also demonstrate that glycolytic activity is significantly associated with treatment prediction of breast cancer patients.

Research Products

• [Journal Article] Prognostic significance of the progesterone receptor status in Ki67-high and -low Luminal B-like HER2-negative breast cancers. (2015)
  • Author(s): Sato K, Miyashita M, Ishida T, Suzuki A, Tada H, Watanabe G, Sato-Tadano A, Watanabe M, Ohuchi N.
  • Journal Title: Breast Cancer Volume: 未定
  • Peer Reviewed / Open Access
• [Presentation] 乳癌原発巣診断における18F-FDG-PET/CTの予後予測因子としての可能性 (2016)
  • Author(s): 原田成美、渡部剛、平川久、伊藤正敏、多田寛、鈴木昭彦、宮下穣、佐藤章子、佐藤千穂、石田孝宣、大内憲明
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2016-04-16
• [Presentation] Hexokinase II: a potent prognostic factor associated with hypoxia-inducible factor-1α possibly through increased glycolytic activity in breast carcinoma. (2014)
  • Author(s): Akiko Sato-Tadano1, Takashi Suzuki2, Takanori Ishida1 , Masakazu Amari4, Kiyoshi Takagi2, Yasuhiro Miki3 , Kentaro Tamaki5, Mika Watanabe6, Hironobu Sasano3,6 and Noriaki Ohuchi
  • Organizer: NIH-Japan-JSPS Symposium 2014
  • Place of Presentation: Bethesda Campus, Maryland USA
  • Year and Date: 2014-10-23 – 2014-10-24
• [Presentation] トリプルネガティブ乳癌におけるHIF-1α誘導遺伝子としてのHexokinaseIIの発現意義 (2014)
  • Author(s): 佐藤章子、石田孝宣、宮下穣、鈴木昭彦、多田寛、渡部剛、根本紀子、藤井里圭、大内憲明
  • Organizer: 第52回日本癌治療学術集会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] 浸潤性乳管癌におけるHIF-1α 誘導遺伝子群の再発予測因子の検討 (2014)
  • Author(s): 佐藤章子、鈴木貴、甘利正和、高木清司、三木康弘、玉城研太朗、渡辺みか、石田孝宣、笹野公伸、大内憲明
  • Organizer: 第22回日本乳癌学会学術総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-07-10 – 2014-07-12
• [Presentation] 浸潤性乳管癌におけるHIF-1a誘導遺伝子としてのHexokinaseIIの発現意義 (2014)
  • Author(s): 佐藤章子、鈴木貴、甘利正和、高木清司、三木康弘、玉城研太朗、渡辺みか、石田孝宣、笹野公伸、大内憲明
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-04-03 – 2014-04-05