Construction of the treatment algorithm for triple negative breast cancer

• Project/Area Number: 26830094
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Tohoku University
• Principal Investigator: Miyashita Minoru 東北大学, 大学病院, 助教 (60710788)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: トリプルネガティブ乳癌 / 腫瘍浸潤リンパ球 / 治療アルゴリズム

Outline of Final Research Achievements

TNBCs with a high CD8+/FOXP3+ ratio were more sensitive to anthracycline and taxane based chemotherapeutic regimens, and the CD8+/FOXP3+ ratio in conjunction with Ki-67 could predict pCR following NAC in TNBC. And we demonstrate that high CD8+ TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pCR following NAC. These parameters could serve as a surrogate one for adjuvant treatment in patients with residual disease in the neoadjuvant setting.

Research Products

• [Journal Article] Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer. (2016)
  • Author(s): Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
  • Journal Title: Eur Radiol. Volume: 26(2) Issue: 2 Pages: 340-341
  • DOI: 10.1007/s00330-015-3847-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tumor microenvironment in invasive lobular carcinoma: possible therapeutic targets. (2016)
  • Author(s): Nakagawa S, Miki Y, Miyashita M, Hata S, Takahashi Y, Rai Y, Sagara Y, Ohi Y, Hirakawa H, Tamaki K, Ishida T, Watanabe M, Suzuki T, Ohuchi N, Sasano H.
  • Journal Title: Breast Cancer Res Treat Volume: 155(1) Issue: 1 Pages: 65-75
  • DOI: 10.1007/s10549-015-3668-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intratumoral estrogen production and actions in luminal A type invasive lobular and ductal carcinomas. (2016)
  • Author(s): Takagi M, Miki Y, Miyashita M, Hata S, Yoda T, Hirakawa H, Sagara Y, Rai Y, Ohi Y, Tamaki K, Ishida T, Suzuki T, Ouchi N, Sasano H.
  • Journal Title: Breast Cancer Res Treat Volume: 156(1) Issue: 1 Pages: 45-55
  • DOI: 10.1007/s10549-016-3739-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study. (2015)
  • Author(s): Miyashita M, Sasano H, Tamaki K, Hirakawa H, Takahashi Y, Nakagawa S, Watanabe G, Tada H, Suzuki A, Ohuchi N, Ishida T.
  • Journal Title: Breast Cancer Res. Volume: 17(1) Issue: 1 Pages: 124-124
  • DOI: 10.1186/s13058-015-0632-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of the progesterone receptor status in Ki67-high and -low Luminal B-like HER2-negative breast cancers. (2015)
  • Author(s): Sato K, Miyashita M, Ishida T, Suzuki A, Tada H, Watanabe G, Sato-Tadano A, Watanabe M, Ohuchi N
  • Journal Title: Breast Cancer Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Androgen receptor and enzymes in lymph node metastasis and cancer reoccurrence in triple-negative breast cancer. (2015)
  • Author(s): McNamara KM, Yoda T, Miki Y, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Nishimura R, Arima N, Tamaki K, Ishida T, Ohuchi N, Sasano H.
  • Journal Title: Int J Biol Markers Volume: Epub ahead of print Issue: 2 Pages: 184-189
  • DOI: 10.5301/jbm.5000132
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating CD8+ and FOXP3+ lymphocytes in triple-negative breast cancer: its correlation with pathological complete response to neoadjuvant chemotherapy. (2014)
  • Author(s): Miyashita M, Sasano H, Tamaki K, Chan M, Hirakawa H, Suzuki A, Tada H, Watanabe G, Nemoto N, Nakagawa S, Ishida T, Ohuchi N
  • Journal Title: Breast Cancer Res Treat Volume: 148(3) Issue: 3 Pages: 525-534
  • DOI: 10.1007/s10549-014-3197-y
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] TNBC術前化学療法施行例における遺残腫瘍内Tumor-infiltrating lymphocytesの意義 (2015)
  • Author(s): 宮下穣
  • Organizer: 第23回日本乳癌学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-07-04
• [Presentation] Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer (2015)
  • Author(s): Minoru Miyashita
  • Organizer: 2015 ASCO Annual Meeting
  • Place of Presentation: Chicago、USA
  • Year and Date: 2015-05-31
  • Int'l Joint Research
• [Presentation] トリプルネガティブ乳癌術前化学療法施行例における腫瘍免疫学的効果予測 (2015)
  • Author(s): 宮下穣
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-04-17
• [Presentation] トリプルネガティブ乳癌における術前化学療法と腫瘍免疫学的効果予測 (2014)
  • Author(s): 宮下穣、石田孝宣、平川久、玉城研太朗、鈴木昭彦、多田寛、渡部剛、佐藤章
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-08-28
• [Presentation] トリプルネガティブ乳癌に対する年代別予後の検討 (2014)
  • Author(s): 宮下穣、石田孝宣、鈴木昭彦、多田寛、渡部剛、佐藤章子、根本紀子、藤井里圭、大内憲明
  • Organizer: 第22回日本乳癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-07-11