Construction of the treatment algorithm for triple negative breast cancer
Project/Area Number |
26830094
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
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Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | トリプルネガティブ乳癌 / 腫瘍浸潤リンパ球 / 治療アルゴリズム |
Outline of Final Research Achievements |
TNBCs with a high CD8+/FOXP3+ ratio were more sensitive to anthracycline and taxane based chemotherapeutic regimens, and the CD8+/FOXP3+ ratio in conjunction with Ki-67 could predict pCR following NAC in TNBC. And we demonstrate that high CD8+ TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pCR following NAC. These parameters could serve as a surrogate one for adjuvant treatment in patients with residual disease in the neoadjuvant setting.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer.2016
Author(s)
Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
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Journal Title
Eur Radiol.
Volume: 26(2)
Issue: 2
Pages: 340-341
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Tumor microenvironment in invasive lobular carcinoma: possible therapeutic targets.2016
Author(s)
Nakagawa S, Miki Y, Miyashita M, Hata S, Takahashi Y, Rai Y, Sagara Y, Ohi Y, Hirakawa H, Tamaki K, Ishida T, Watanabe M, Suzuki T, Ohuchi N, Sasano H.
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Journal Title
Breast Cancer Res Treat
Volume: 155(1)
Issue: 1
Pages: 65-75
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Intratumoral estrogen production and actions in luminal A type invasive lobular and ductal carcinomas.2016
Author(s)
Takagi M, Miki Y, Miyashita M, Hata S, Yoda T, Hirakawa H, Sagara Y, Rai Y, Ohi Y, Tamaki K, Ishida T, Suzuki T, Ouchi N, Sasano H.
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Journal Title
Breast Cancer Res Treat
Volume: 156(1)
Issue: 1
Pages: 45-55
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study.2015
Author(s)
Miyashita M, Sasano H, Tamaki K, Hirakawa H, Takahashi Y, Nakagawa S, Watanabe G, Tada H, Suzuki A, Ohuchi N, Ishida T.
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Journal Title
Breast Cancer Res.
Volume: 17(1)
Issue: 1
Pages: 124-124
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Androgen receptor and enzymes in lymph node metastasis and cancer reoccurrence in triple-negative breast cancer.2015
Author(s)
McNamara KM, Yoda T, Miki Y, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Nishimura R, Arima N, Tamaki K, Ishida T, Ohuchi N, Sasano H.
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Journal Title
Int J Biol Markers
Volume: Epub ahead of print
Issue: 2
Pages: 184-189
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor-infiltrating CD8+ and FOXP3+ lymphocytes in triple-negative breast cancer: its correlation with pathological complete response to neoadjuvant chemotherapy.2014
Author(s)
Miyashita M, Sasano H, Tamaki K, Chan M, Hirakawa H, Suzuki A, Tada H, Watanabe G, Nemoto N, Nakagawa S, Ishida T, Ohuchi N
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Journal Title
Breast Cancer Res Treat
Volume: 148(3)
Issue: 3
Pages: 525-534
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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