Elucidation of anti-tumor acquired immune activation mechanism by Sendai viral particles
| Project/Area Number |
26830106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Osaka University |
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Principal Investigator |
Saga Kotaro 大阪大学, 医学(系)研究科(研究院), 助教 (00563389)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 抗腫瘍免疫 / センダイウイルス |
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| Outline of Final Research Achievements |
In this study, we will identify a novel receptor for F protein on inactivated Sendai virus particle (HVJ-E) and elucidate the mechanism of acquired immune activation against cancer via the receptor stimulation. Although we have not identified the novel receptor for F protein yet, we have found several candidate genes by mass spectrography. Moreover, we have revealed that IL-18, which is secreted from F protein-stimulated macrophage, exhibits the important effect for T cell activation.
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Report
(3 results)
Research Products
(1 results)
