Elucidation of anti-tumor acquired immune activation mechanism by Sendai viral particles

Research Project

Project/Area Number	26830106
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor therapeutics
Research Institution	Osaka University
Principal Investigator	Saga Kotaro 大阪大学, 医学(系)研究科(研究院), 助教 (00563389)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	抗腫瘍免疫 / センダイウイルス
Outline of Final Research Achievements	In this study, we will identify a novel receptor for F protein on inactivated Sendai virus particle (HVJ-E) and elucidate the mechanism of acquired immune activation against cancer via the receptor stimulation. Although we have not identified the novel receptor for F protein yet, we have found several candidate genes by mass spectrography. Moreover, we have revealed that IL-18, which is secreted from F protein-stimulated macrophage, exhibits the important effect for T cell activation.